Bisphosphonates are the cornerstone of treatment for osteoporosis. These agents are generally safe and well-tolerated, but concerns have emerged about adverse effects related to long-term use, namely osteonecrosis of the jaw and atypical femur fractures. For most patients at moderate or high risk of fracture, the benefits of treatment far outweigh these serious but rare risks. Bisphosphonates a...

Controlling spatiotemporal chaos in excitable media by applying low-amplitude perturbations locally is of immediate applicability, e.g., in treating ventricular fibrillation, a fatal disturbance in the normal rhythmic functioning of the heart. We look at a mechanism of control by the local application of a series of biphasic pulses, i.e., involving both positive and negative stimulation. This r...

The dual systems model posits that adolescent risk-taking results from an imbalance between a cognitive control system and an incentive processing system. Researchers interested in understanding the development of adolescent risk-taking use a diverse array of behavioral and self-report measures to index cognitive control and incentive processing. It is currently unclear whether different measur...

BACKGROUND Since 2011, we have witnessed the rise of 'dark net' drug marketplaces known as cryptomarkets. Cryptomarkets operate on the same model as eBay as they provide a platform where authorized vendors can set up a virtual shop and place listings. Building on a growing body of literature that seeks to understand cryptomarket participants, this paper seeks to explain the decision of cryptoma...

A questionnaire on the pattern of drug taking was completed by 185 patients with chronic airflow obstruction. Of these, 49% admitted to taking their prescribed therapy regularly and 33% could be regarded as being fully compliant. The use of increasing numbers of drugs was not accompanied by a fall in compliance. Regular drug taking was better in patients (particularly females) with asthma than ...

Burma.By Roy K. Anderson,, f.r.s.a. Thacker, Spink and Co., Calcutta. Rs. 4. Pp. 104. This is a most interesting little book. It is very fully illustrated and it 'breathes of atmosphere ; of chopsticks and fowl chow ; of nights in Chinatown ; of the temple of Heaven and of the sons of Belial,?the latter being the respectable, soi-disant and easy-going merchants who, under the cloak of general m...

A follow-up study of girls in a London remand home during the years 1966-8 showed that 20.6% of those taking non-narcotic drugs on admission, but only 1% of non-drug-taking control admissions, had used narcotics by June 1970. Narcotic use on admission and progression to narcotic use were associated with frequent drug taking, marked involvement in a drug milieu, and a high incidence of personal ...

Attention deficit hyperactivity disorder (ADHD) is characterized by 3 core symptoms: inattention, hyperactivity, and impulsivity.1,2 The presence and severity of these symptoms vary and characterize the 3 subtypes of ADHD: predominantly inattentive (10% to 20%), predominantly hyperactive or impulsive (5% to 10%), and combined inattentive and hyperactive (70% to 80%).3,4 Children with ADHD might...

Prolonged adherence to neuroleptic medication by patients with schizophrenia involves many complex issues. These vary markedly from case to case, and poor compliance is effectively resolved only when the attitudes and behaviors of individual cases are carefully analyzed. This article describes some of the aspects that commonly contribute to deficient compliance in clinical practice, and offers ...