Seminal works in the application of design science research (DSR) in IS emphasize the importance of evaluation. However, discussion of evaluation activities and methods is limited and typically assumes an ex post perspective, in which evaluation occurs after the construction of an IS artifact. Such perspectives can assume that the evaluation is an empirical process and its methods can be select...

BACKGROUND Gefitinib is active in patients with pretreated non-small-cell lung cancer (NSCLC). We evaluated the activity and toxicity of gefitinib first-line treatment in advanced NSCLC followed by chemotherapy at disease progression. PATIENTS AND METHODS In all, 63 patients with chemotherapy-naive stage IIIB/IV NSCLC received gefitinib 250 mg/day. At disease progression, gefitinib was replac...

The Dynamic Source Routing protocol (DSR) is a simple and efficient routing protocol designed specifically for use in multi-hop wireless ad hoc networks of mobile nodes. DSR allows the network to be completely self-organizing and self-configuring, without the need for any existing network infrastructure or administration. The protocol is composed of the two main mechanisms of "Route Discovery" ...

Dynamic Source Routing protocol (DSR) has been accepted Itself as one of the distinguished and dominant routing protocols for Mobile Ad Hoc Networks (MANETs). From various performance analysis and results, it is shown that DSR has been an outstanding routing protocol that outperforms consistently than any other routing protocols. But it could not pervade the same place when the performance was ...

The idea of a role for DSR (doubly-special relativity) in quantum gravity finds some encouragement in a few scenarios, but in order to explore some key conceptual issues it is necessary to find a well-understood toy-quantum-gravity model that is fully compatible with the DSR principles. Perhaps the most significant source of encouragement comes from the recent proposal of a path for the emergen...

In many different ways, Deformed Special Relativity (DSR) has been argued to provide an effective limit of quantum gravity in almost-flat regime. Unfortunately, DSR is up to now plagued by many conceptual problems (in particular how it describes macroscopic objects) which forbids a definitive physical interpretation and clear predictions. Here we propose a consistent framework to interpret DSR....

The two regions of the Epstein-Barr virus genome carrying partially homologous clusters of short tandem repeats (DSL and DSR [duplicated sequences, left and right, respectively] ) are transcribed into polyadenylated RNA upon spontaneous or chemical induction of the lytic virus cycle. In Raji, an Epstein-Barr virus genome carrying a nonproducer cell line, transcription of DSL and DSR is only obs...

DT neutron yield (Y(n)), ion temperature (T(i)), and down-scatter ratio (dsr) determined from measured neutron spectra are essential metrics for diagnosing the performance of inertial confinement fusion (ICF) implosions at the National Ignition Facility (NIF). A suite of neutron-time-of-flight (nTOF) spectrometers and a magnetic recoil spectrometer (MRS) have been implemented in different locat...

We estimated nesting success of a breeding bird assemblage in the central Monte Desert in four breeding seasons (1995–1999). We analyzed the effect of year, period within the breeding season, nest type, and nest location on daily survival rates (DSR). Averaged nesting success of passeriforms in natural habitats was very low ( 20% on average, n=12 species). DSR tended to be lower during the egg-...

Enhancement of neurotransmission mediated at N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) may be beneficial in post-traumatic stress disorder (PTSD). d-serine (DSR) is an endogenous full agonist at the NMDAR-associated glycine modulatory site. Twenty-two chronic PTSD outpatients were randomly assigned to participate in a 6-wk double-blind, placebo-controlled, crossover trial with...