Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from endosomal lumen into the host cell cytosol. Here, DTA ADP-ribosylates elongation factor 2 inhibits protein synthesis and leads to cell death. The...

Abstract—Human beings have the ability to make logical decisions. Although human decision making is often optimal, it is insufficient when huge amount of data is to be classified. Medical dataset is a vital ingredient used in predicting patient’s health condition. In other to have the best prediction, there calls for most suitable machine learning algorithms. This work compared the performance ...

This text describes the first application of a novel path flow and origin/destination (OD) matrix estimator for iterated dynamic traffic assignment (DTA) microsimulations. The presented approach, which operates on a trip-based demand representation, is derived from an agent-based DTA calibration methodology that relies on an activity-based demand model. The objective of this work is to demonstr...

The new computational algorithms emerging in the data mining literature--in particular, the self-organizing map (SOM) and decision tree analysis (DTA)--offer qualitative researchers a unique set of tools for analyzing health informatics data. The uniqueness of these tools is that although they can be used to find meaningful patterns in large, complex quantitative databases, they are qualitative...

Solidification of pure aluminum without and with a magnetic field has been investigated by differential thermal analysis (DTA). DTA curves showed that the nucleation temperature of pure aluminum was decreased as a magnetic field strength increased although its melting process was almost not influenced. The nucleation suppression could be attributed to the increase of the solidliquid interfacial...