نتایج جستجو برای: dual targeting

تعداد نتایج: 300248  

Journal: :Molecular biology and evolution 2011
Marcelo M Brandão Marcio C Silva-Filho

Aminoacyl-transfer RNA (tRNA) synthetases (aaRS) are key players in translation and act early in protein synthesis by mediating the attachment of amino acids to their cognate tRNA molecules. In plants, protein synthesis may occur in three subcellular compartments (cytosol, mitochondria, and chloroplasts), which requires multiple versions of the protein to be correctly delivered to its proper de...

2001
Laurence H. Meyer

There is widespread agreement that price stability (in practice, low and stable inflation) should be an objective of monetary policy. This agreement is reflected both in the mandates set for monetary policy by governments and in the practice of central banks. Several other important questions about the objectives for monetary policy are less settled: Should there be other objectives? If there a...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015
Colin F Greineder Jacob B Brenza Ronald Carnemolla Sergei Zaitsev Elizabeth D Hood Daniel C Pan Bi-Sen Ding Charles T Esmon Ann Marie Chacko Vladimir R Muzykantov

Anchoring pharmacologic agents to the vascular lumen has the potential to modulate critical processes at the blood-tissue interface, avoiding many of the off-target effects of systemically circulating agents. We report a novel strategy for endothelial dual targeting of therapeutics, which both enhances drug delivery and enables targeted agents to partner enzymatically to generate enhanced biolo...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Hang-Hui Wang Yi-Xin Song Min Bai Li-Fang Jin Ji-Ying Gu Yi-Jin Su Long Liu Chao Jia Lian-Fang Du

The aim was to determine whether ultrasound targeted microbubble destruction (UTMD) promotes dual targeting of HSP72 and HSC70 for therapy of castration-resistant prostate cancer (CRPC), to improve the specific and efficient delivery of siRNA, to induce tumor cell specific apoptosis, and to find new therapeutic targets specific of CRPC.VCaP cells were transfected with siRNA oligonucleotides. HS...

2015
Chuan Liu Hongyu Ding Xiaoxi Li Christian P Pallasch Liya Hong Dianwu Guo Yi Chen Difei Wang Wei Wang Yajie Wang Michael T Hemann Hai Jiang

Genotoxic drugs constitute a major treatment modality for human cancers; however, cancer cells' intrinsic DNA repair capability often increases the threshold of lethality and renders these drugs ineffective. The emerging roles of HDACs in DNA repair provide new opportunities for improving traditional genotoxic drugs. Here, we report the development and characterization of CY190602, a novel bend...

Journal: :Journal of biomedical optics 2012
Yu-Hsin Wang Ai-Ho Liao Jui-Hao Chen Churng-Ren Chris Wang Pai-Chi Li

This study investigates a photoacoustic/ultrasound dual-modality contrast agent, including extending its applications from image-contrast enhancement to combined diagnosis and therapy with site-specific targeting. The contrast agent comprises albumin-shelled microbubbles with encapsulated gold nanorods (AuMBs). The gas-filled microbubbles, whose diameters range from submicrometer to several mic...

Journal: :Cancer research 2012
Nicolas Floc'h Carolyn Waugh Kinkade Takashi Kobayashi Alvaro Aytes Celine Lefebvre Antonina Mitrofanova Robert D Cardiff Andrea Califano Michael M Shen Cory Abate-Shen

Although the prognosis for clinically localized prostate cancer is now favorable, there are still no curative treatments for castration-resistant prostate cancer (CRPC) and, therefore, it remains fatal. In this study, we investigate a new therapeutic approach for treatment of CRPC, which involves dual targeting of a major signaling pathway that is frequently deregulated in the disease. We found...

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