نتایج جستجو برای: dub
تعداد نتایج: 900 فیلتر نتایج به سال:
The Krüppel-like factor 5 (KLF5) has been suggested to promote breast cell proliferation, survival and tumorigenesis. KLF5 protein degradation is increased by several E3 ubiquitin ligases, including WWP1 and SCFFbw7, through the ubiquitin-proteasome pathway. However, the deubiquitinase (DUB) of KLF5 has not been demonstrated. In this study, we identified ATXN3L as a KLF5 DUB by genome-wide siRN...
There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function across multiple cell types. Here, we show that FOXK2 binds to the SIN3A and PR-DUB complexes. The PR-DUB complex contains the important tumour suppressor protein, the deubi...
BACKGROUND Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin (Ub) or ubiquitin-like gene products, remodel polyubiquitin(-like) chains on target proteins, and counteract protein ubiquitination exerted by E3 ubiquitin-ligases. A wealth of studies has established the relevance of DUBs to the control of physiological processes whose subversion is known to cause cellular transfor...
pretreatment of adults of iraq strain of afhstephenst with a sub-letlial dose of pcrmethrin resulted in a 65% enliancemenl of tolerance to this insecticide. similarly, pre-exposure of dub-lpr larvae to a sub-lethal dose of pcrmethrin resulted in increased tolerance to pcrmethrin. for the sensitive ind-s strain, the inductive effect was smaller. tiie results of bioassays of resistant and suscept...
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