Magnetically-actuated soft robots for medical applications are required to be functional, biocompatible, as well capable of robust motion inside human organs. In this paper, a ring-shaped magnetic robot, with flexible biopolymeric film coating, on mucus-coated surfaces is designed and investigated. The made from chitosan–glycerol (C–G) solution endows the robot locomotion capabilities diverse g...

The unidirectional release buccal patches of carbamazepine (CBZ) were designed in total of 36 formulations using a 32 full factorial design. Different hydrophilic polymers were used in the formulation along with chitosan-HPMC matrix. The thickness of the prepared patches varied between 0.3 ± 0.10 and 0.5 ± 0.15 mm. The mass of the patches varied from 142.4 ± 0.22 and 160.2 ± 0.13 mg. The pH of ...

mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. several synthetic polymers are in use for this purpose. since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controlled del...

Curcumin (Cur) is a striking anticancer agent, but its low aqueous solubility, poor absorption, hasty metabolism, and elimination limit its oral bioavailability and consequently hinder its development as a drug. To redress these limitations, amphiphilic chitosan (CS) conjugate with improved mucoadhesion and solubility over a wider pH range was developed by modification with hydrophobic acryloni...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

The two major problems in the development of new drugs are low aqueous solubility and oral bioavailability. Although, drug delivery via route is most preferred for years but it also has some drawbacks. Various techniques improving have been developed, however success these depends on physical chemical properties under development. In recent years, mucoadhesive gained high popularity comparison ...