Resective neurosurgery carries the risk of postoperative cognitive deterioration. The concept of 'hub (over)load', caused by (over)use of the most important brain regions, has been theoretically postulated in relation to symptomatology and neurological disease course, but lacks experimental confirmation. We investigated functional hub load and postsurgical cognitive deterioration in patients un...

We propose a novel hub location model that jointly eliminates some of the traditional assumptions on structure network and discount as result economies scale in an effort to better reflect real-world logistics transportation systems. Our extends literature various facets: instead connecting nonhub nodes directly nodes, we consider routes with stopovers; pairs hubs directly, design can visit sev...

in this paper, we study the problem of integrated capacitated hub location problem and seat inventory control considering concept and techniques of revenue management. we consider an airline company maximizes its revenue by utilizing the best network topology and providing proper booking limits for all itineraries and fare classes. the transportation system arises in the form of a star/star net...

The increasing demand for multimodal freight transportation makes the expansion of new secondary hubs necessary. carbon tax has also received attention from various sectors due to development requirements green transportation. Therefore, this study proposed a transport hub location problem, where emissions are specifically considered achieve strategic planning. A mixed integer non-linear progra...

We investigate a variant of the many-to-many hub location-routing problem which consists in partitioning the set of nodes of a graph into routes containing exactly one hub each, and determining an extra route interconnecting all hubs. A variable neighborhood descent with neighborhood structures based on remove/add, swap and exchange moves nested with routing and location operations is used as a...

Available online 30 January 2009

In this paper, we introduce a new hub-and-spoke structure for service networks based on round-trips as practiced by some transport providers. This problem is variant of Uncapacitated Hub Location Problem wherein the spoke nodes allocated to hub node form (cycles) starting from and ending node. motivated two real-life practices in logistics runaway connections with their associated economies sca...