نتایج جستجو برای: early life stress
تعداد نتایج: 1736970 فیلتر نتایج به سال:
Although childhood is connected with high neuroplasticity changes, but because of the immaturity of the neural and cognitive systems, it is ready to grow developmental deviations and future susceptibility for neuropsychological disorders. Young children face cognitive, emotional, and linguistic limits that may lead them more vulnerable to post-traumatic stress disorder (PTSD). PTSD prevalence d...
BACKGROUND A substantial body of experimental and epidemiological evidence has been accumulated suggesting that stressful events in early life including acute perinatal stress, maternal deprivation or separation, and variation in maternal care may lead to neuroendocrine perturbations thereby affecting reproductive performance, cognitive functions, and stress responses as well as the risk for in...
Stress exposure during early-life development can programme individual brain and physiology. The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback. This reduced feedback efficiency usually results from a reduced level of the glucocorticoid receptor (GR)...
While the negative effects of early-life stress on children's developmental outcomes are well documented, we know little about how these processes unfold and which children are more susceptible to these exposures. In this article, I outline how studying the effects of early-life stress on children's development can be advanced by considering how epigenetic processes may contribute to the emerge...
Aberrant serotonin (5-HT) signalling and exposure to early life stress have both been suggested to play a role in anxiety- and impulsivity-related behaviours. However, whether congenital 5-HT deficiency × early life stress interactions influence the development of anxiety- or impulsivity-like behaviour has not been established. Here, we examined the effects of early life maternal separation (MS...
Early-life stress is a key risk factor for the development of neuropsychiatric disorders later in life. Neuronal cell adhesion molecules have been strongly implicated in the pathophysiology of psychiatric disorders and in modulating social behaviors associated with these diseases. Neuroligin-2 is a synaptic cell adhesion molecule, located at the postsynaptic membrane of inhibitory GABAergic syn...
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