Neonatal sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Signs and symptoms of sepsis are nonspecific, and empiric antimicrobial therapy is promptly initiated after obtaining appropriate cultures. However, many preterm and low birth weight infants who do not have infection receive antimicrobial agents during hospit...

Results: We found high percentage of expression of CD64 on neutrophils in patients (67.73 ± 24.74) when compared with controls (8.19 ± 3.64) and also their percentage of expression was higher in culture positive sepsis (76.25 ± 29.07) than culture negative sepsis (42.21 ± 33.24). In the present study, I/T ratio >0.2 had a sensitivity, specificity, PPV, NPV and accuracy i.e. 70.0%, 72.0%, 33.3%,...

A prospective observational study was conducted in a neonatal unit of referral teaching hospital North India with an aim to the bacteriological profile and sensitivity pattern referred neonates. During this period one year, incidence culture positive sepsis 34 % among which gram-negative bacilli predominated both early onset late sepsis. In sepsis, predominant organism Klebsiella pneumoniae fol...

Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α ) test in NS. Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane Library between March 1994 and August 2013. Accordingly, 347 studies were collected totally, in ...

Abstract Objective: To assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. Methods: This was prospective study conducted over a period of one year from December 2009 to November 2010 in neonatal intensive care unit of DDUH Hospital, a tertiary care hospital in Delhi, North India. All babies who were admitted during this perio...

Sepsis is a life-threatening condition which responsible for high proportion of intra-hospital deaths and related healthcare costs each year. Early detection treatment sepsis episodes critical, since an early may highly improve prognosis. This study proposed original method to increase the interpretability set machine learning models onset. Open data from electronic medical records 40,336 patie...

abstract objective: to assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. methods: this was prospective study conducted over a period of one year from december 2009 to november 2010 in neonatal intensive care unit of dduh hospital, a tertiary care hospital in delhi, north india. all babies who were admitted during this perio...

OBJECTIVE To identify interventions that reduce the attack rate for early-onset group B streptococcal (GBS) sepsis in neonates. STUDY DESIGN Literature review and reanalysis of published data. RESULTS The rate of early-onset GBS sepsis in high-risk neonates can be reduced by administration of antibiotics. Treatment during pregnancy (antepartum prophylaxis) fails to reduce maternal GBS colon...

BACKGROUND We estimate the effect of antibiotics given in the intrapartum period on early-onset neonatal sepsis in Dhaka, Bangladesh using propensity score techniques. METHODS We followed 600 mother-newborn pairs as part of a cohort study at a maternity center in Dhaka. Some pregnant women received one dose of intravenous antibiotics during labor based on clinician discretion. Newborns were f...

INTRODUCTION Neutrophil CD64 has been proposed as an early marker of sepsis. This study aims to evaluate the diagnostic utility of neutrophil CD64 for identification of early-onset sepsis in preterm neonates. METHODS The prospective study was conducted in a neonatal intensive care unit between November 2010 and June 2011. Preterm neonates in whom infection was suspected when they were <12 hou...