نتایج جستجو برای: early sepsis
تعداد نتایج: 723322 فیلتر نتایج به سال:
Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA and intracellular protein levels increase during early sepsis and remain elevated in Gr1+CD11b+ MDSCs after pro-inflammatory sepsis transitions to the later chronic anti-inflammatory and immunosuppressive phenotype. The purpose of this stu...
Early fluid resuscitation, antimicrobials, early excision, and grafting have improved survival in the early postburn period; however, a significant incidence of pneumonia-related sepsis occurs after burn injury, often progressing to multiple organ failure. Recent studies have suggested that this initial injury (burn injury) primes the subject, producing an exaggerated response to a second insul...
Globally, an estimated 500,000 newborns die each year from serious neonatal infections, which account for about 15% of all neonatal deaths. “Suspected sepsis” is one of the most common reasons for admission to the neonatal intensive care unit (NICU). The challenge to the physician has always been trying to differentiate newborns with early onset sepsis from other non-infectious pathology whose ...
OBJECTIVE Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that sirtuins (SIRTs) modulate this transition. Here, we investigated the role of sirtuins, especially ...
The early recognition of severe sepsis is important; however, early identification of severe sepsis can be challenging, especially in the prehospital setting. As previous research has shown, advanced notification of time-sensitive disease states by prehospital personnel can improve outcomes and time to initiation of treatments. Prehospital personnel can potentially impact outcomes in sepsis thr...
Early diagnosis of sepsis is critical for successful treatment. The clinical value of DcR3 in early diagnosis of sepsis was determined in a dynamic follow-up study. Alterations in plasma levels of DcR3, PCT, CRP, and IL-6 were measured by ELISA and compared among patients with sepsis (n = 134), SIRS (n = 60) and normal adults (n = 50). Correlations and dynamic patterns among the biomarkers, APA...
Although myocarditis is uncommon in neonates, a wide variety of infectious pathogens can result in myocarditis, including viruses, bacteria, rickettsia, fungi, and protozoa. Viruses are most often the infectious disease found to cause acute myocarditis. On the other hand, bacterial myocarditis (BM) is an unusual cause of infectious myocarditis. BM is commonly seen in the context of sepsis or as...
et al in their study in 2001 randomly assigned 263 patients admitted to emergency department with severe sepsis or septic shock to receive either six hours of early goal-directed therapy (egdt) or standard therapy before admission to the intensive care. 130 were randomly assigned to egdt and 133 to standard therapy. demographic characteristic of patients were the same, but in hospital mortality...
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