Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence metaplastic ectopic bone in lungs and less frequent patients without clear background diseases. DPO very small calcific nodules, often with mature located both peripheral areas lungs. Two patterns have been recognized dendriform nodular. The type common coral-like network spicula...

The motor protein Kif3a and primary cilia regulate important developmental processes, but their roles in skeletogenesis remain ill-defined. Here we created mice deficient in Kif3a in cartilage and focused on the cranial base and synchondroses. Kif3a deficiency caused cranial base growth retardation and dysmorphogenesis, which were evident in neonatal animals by anatomical and micro-computed tom...

Ossification of the Posterior Longitudinal Ligament (OPLL) is a disease that is characterized by the ectopic calcification of the ligament; however, the pathogenesis of OPLL remains to be investigated. We attempted to identify the in vivo role of Runx2, a master regulator of osteoblast differentiation and skeletal mineralization, in the pathogenesis of OPLL. The expression of Runx2 in the ligam...

Endometrial calcification along with ossification is an uncommon clinical entity. Most of the cases are asymptomatic or present with secondary infertility. Endometrial ossification associated with repeated abortions has been reported very infrequently. Here we report a case of endometrial calcification with ossification  due to retained fetal bony tissue in a 38 year old symptomatic female havi...

ectopic thyroid tissue results from abnormal embryologic development and migration of the thyroid gland. true malignant transformation in ectopic thyroid tissue is extremely rare and is always diagnosed after surgical excision of the lesion by pathology examinations. there are well-documented cases of ectopic thyroid cancer while primary tumoral lesion occurs in the orthotopic thyroid, but only...

endometrial calcification along with ossification is an uncommon clinical entity. most of the cases are asymptomatic or present with secondary infertility. endometrial ossification associated with repeated abortions has been reported very infrequently. here we report a case of endometrial calcification with ossification  due to retained fetal bony tissue in a 38 year old symptomatic female havi...