In septic shock, reversible cardiac dysfunction starts within 24 h. Myocardial depressant factors are thought to cause myocyte dysfunction, resulting in alterations of intrinsic cardiac function. Nitric oxide is a myocardial depressant factor candidate. Here we identify endotoxin-induced myocarditis (EIM) a previously uncharacterized pathophysiological entity. Features of EIM include differenti...

OBJECTIVE To test a method for performing electrical impedance myography (EIM) in the mouse hind limb for the assessment of disease status in neuromuscular disease models. METHODS An impedance measuring device consisting of a frame with electrodes embedded within an acrylic head was developed. The head was rotatable such that data longitudinal and transverse to the major muscle fiber directio...

In this study, we investigate the interaction between the tropical Intraseasonal Oscillation (ISO) and midlatitude atmospheric low-frequency variability, using observational data and numerical models, with a special emphasis on the role of the synoptic eddy feedback. A statistical closure for the synoptic eddy-to-low frequency flow feedback is constructed, based on a singular value decompositio...

AIM IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study. METHODS Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: 317/302, mean age at presentation: 38.3 years, average disease durati...

The origin of low-frequency variability in the midlatitude jet is investigated using a two-level baroclinic channel model. The model state fields are separated into slow and fast components using intermediate timescale averaging. In the equation for the fast variables the nonlinear wave–wave interactions are parameterized as a stochastic excitation. The slowly varying ensemble mean eddy fluxes ...

Animal models serve a vital role in deep venous thrombosis (DVT) research in order to study thrombus formation, thrombus resolution and to test potential therapeutic compounds. New compounds to be utilized in the treatment and prevention of DVT are currently being developed. The delivery of potential therapeutic antagonist compounds to an affected thrombosed vein has been problematic. In the co...

The formation mechanism of the Santa Cruz eddy (SCE) is investigated using the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5). Simulations of 25–26 August 2000 showed that two eddy instances formed on that night, a finding supported by observations. The two eddies had similar behavior: they both formed in the sheltered Santa Cruz, C...

The interaction between synoptic eddy and low-frequency flow (SELF) has been recognized for decades to play an important role in the dynamics of the low-frequency variability of the atmospheric circulation. In this three-part study a linear framework with a stochastic basic flow capturing both the climatological mean flow and climatological measures of the synoptic eddy flow is proposed. Based ...

A model for the kinematic eddy viscosity has been developed which accounts for the turbulence produced as a result of jet interactions between adjacent streams as well as the turbulence initially present in the streams. In order to describe the turbulence contribution from jet interaction, the eddy viscosity suggested by Prandtl has been adopted, and a modification has been introduced to accoun...