With recent technological advances that enable DNA cleavage at specific sites in the human genome, it may now be possible to reverse inborn errors, thereby correcting a mutation, at levels that could have an impact in a clinical setting. We have been developing gene editing, using single-stranded DNA oligonucleotides (ssODNs), as a tool to direct site specific single base changes. Successful ap...

†College of Mechanical and Power Engineering, East China University of Sciences and Technology, Meilong Road 130, Shanghai 200237, P.R. China ‡Department of Engineering Machinery, Shandong Jiaotong University, 5 Jiaoxiao Road, Jinan, Shandong 250023, P.R. China §School of Mechanical Engineering, Shandong University, 73 Jingshi Road, Jinan 250061, P.R. China ¶Department of Airspace Engineering, ...

This paper demonstrates magnetic three-degree-of-freedom (3-DOF) closed-loop position and 2-DOF open-loop orientation control of a mockup magnetic capsule endoscope in fluid with a single permanent magnet positioned by a commercial 6-DOF robotic manipulator, using feedback of only the 3-DOF capsule position measured by a localization system, with application in capsule endoscopy of a fluid-dist...

Hybrid Control for robots in contact with the environment is intended to separately impose end-effector motion and contact force along different directions, determined on the base of an available environment model. Since measured forces and velocities in practice do not agree exactly with the model, some filtering procedure is required for recovering consistence, before the control phase. In th...

right angled component C 1. For the moment, let us ignore frictional forces. C 1 is firmly attached to a gripper, as indicated in the figure by the ground symbol. The vector g indicates the direction of a uniform gravity field. In the orientation shown in Figure 1(a), the assembly is unstable under the influence of gravity. Gravitational forces produce a downward translational motion on compone...

We investigated the use of a new haptic device called the DigiHaptic in a 3D steering task. Unlike other devices intended to interact in 3D with one end-effector, the DigiHaptic has three levers that the user may handle simultaneously or not in elastic mode to rate control objects. We compared it to the SpaceMouse another elastic device to evaluate the influence that degrees of freedom (DOF) se...

The impedance matrices of independent point fingers of a multifingered gripper map to the impedance matrix of a grasped workpart. We find that in a planar geometry, three fingers are enough to allow an unrestricted range of workpart impedances, if finger impedances are selectable. In a spatial geometry however, five fingers are necessary for the broadest range of workpart impedances, and even s...

An approach to make use of available potentials of uncalibrated vision-guided robots is introduced. It allows the robot to manipulate differently shaped objects that may be located anywhere in its workspace, even if they are not visible in the initial fields of view of the cameras. Key points of the approach are the conversion of passive "watching" into active "seeing", so that the fields of ca...

This work deals with the problem of end-effector trajectory modification for a robot manipulator when it must respond to unexpected changes in target location. Trajectory modification and corrections are particularly important in dealing with dynamic tasks. In this paper, we present and discuss the superposition strategy derived from the study of arm trajectory modification in human subjects. A...

the role of microbiota in health and disease is the subject of rigorous investigation. several studies have demonstrated that microbiota and the pattern-recognition receptors contribute to intestinal tumourigenesis; the exact mechanism of which is still obscure. myd88 is the downstream effector of all toll-like receptors (tlrs) except tlr3. however, the alternative myd88-independent pathway is ...