Branched chain a-ketoacid dehydrogenase (BCKDH) deficiency results in maple syrup urine disease (MSUD). We examined the molecular basis of familial cases ofMSUD by analyzing the activity, subunit structure, mRNA sequence, and genome structure of the affected enzyme. The BCKDH activity in the proband with MSUD was 6% ofthe normal control level. Immunoblot analysis revealed that the ElB subunit o...

Current treatments for pancreatic ductal adenocarcinoma (PDA) are ineffective, making this the 4th leading cause of cancer deaths. Sunitinib is a broad-spectrum inhibitor of tyrosine kinase receptors mostly known for its anti-angiogenic effects. We tested the therapeutic effects of sunitinib in pancreatic cancer using the Ela-myc transgenic mouse model. We showed that Ela-myc pancreatic tumors ...

Several authors relate accumulation (or precipitation) at the glacier equilibrium-line altitude (ELA) to summer mean temperature using exponential or power-law functions. I analyze the accumulation–temperature relation at the ELA with a degree-day model using data from the 1992 paper by A. Ohmura and others. The dataset includes estimates at the ELA of winter balance and of ‘winter balance plus...

In the present work a novel C,N-cyclometalated benzimidazole Ru(ii) arene complex (GY34) was characterized by applying an alternative, diverse approach considering both chemical and biological aspects. RP-HPLC-ICP-MS and RP-HPLC-ESI-MS analysis proved that GY34 in both RPMI-1640 cell medium and ammonium acetate buffer was transformed into several subspecies and the importance of evaluating and ...

ELA (Error Level Analysis) is a digital image analysis technique that has gained popularity in recent years the field of modern forensics. It powerful method can help experts determine if an been altered or manipulated any way. works by analyzing levels compression within and identifying areas have edited at different level than rest image. This information be crucial criminal investigations, w...

The pattern and magnitude of glacier equilibrium-line altitude (ELA) lowerings in the tropics during the last glacial maximum (LGM) are topics of current debate. In the northern tropics, paleo-ELA data are particularly limited, inhibiting the ability to make regional and large-scale paleoclimatic inferences. To improve these records, nine paleo-glaciers in the Venezuelan Andes were reconstructe...