Germline breast cancer 1 (BRCA1) variants are associated with a high risk of breast and ovarian cancers. Many BRCA1-mediated cancers are initially responsive to platinum-based therapy; however, resistance commonly develops. The BRCA1185delAG mutation is common in the Ashkenazi Jewish population and has been thought to result in loss of function due to the introduction of a stop codon in the 5' ...

According to British author Graham Hancock, one can get quite rich attending to the poor. His book, Lords of Poverty, * is a scathing indictment of official "overseas development assistance," that collection of efforts of bilateral and multilateral organizations allegedly about the business of transferring resources from the rich, industrialized North to the poor, underdeveloped South. Hancock'...

Epilepsy holds an almost unique place in English criminal law. It has resulted in two appeals to the Judicial Committee of the House of Lords, the highest appeal court in the land. This in turn has led to a pair of legal decisions which in many ways have shaped the development of the defence of insanity and its relationship to automatism. This report will provide a unique insight into how the c...