Lesions of the nucleus tractus solitarius (NTS) were studied to determine whether they elevate plasma vasopressin levels and, if so, whether these elevated levels of vasopressin contribute to the hypertension caused by NTS lesions. Bilateral electrolytic lesions of the NTS caused acute, severe hypertension in rats anesthetized with chloralose and in conscious, freely moving rats. After placemen...

Rats with electrolytic lesions of the nucleus basalis magnocellularis were compared to sham-lesioned rats in the retention of a continuously reinforced lever-pressing response and in the acquisition and reversal of a visual discrimination task. The muscarinic agonist pilocarpine, in conjunction with the peripheral muscarinic antagonist methyl-scopolamine, was administered in three doses to subs...

The suprachiasmatic nucleus (SCN) of the hypothalamus is a precise timekeeper that controls and synchronizes the circadian period of countless physiological and behavioural functions and entrains them to the 24 h light/dark cycle. We examined the possibility that it is also indirectly involved in measurement of a briefer interval by observing the effects of lesions targeted at the SCN, and abol...

Hippocampal theta rhythm was analyzed in rats subjected to bilateral, electrolytic lesions of the lateral hypothalamic (LH) region at different levels of its rostro-caudal axis. It was found that damage to the LH disturbed the hippocampal theta activity both during waking and paradoxical sleep. The main effect consisted in the lowering of the theta frequency. Typically, a decrease of frequency ...

A five step investigation was carried out to gain a better understanding of the morbidity that accompanied the development of telangiectasia on aluminium workers and to find its cause. Fifty workers with multiple telangiectasia when matched with normal controls showed the same amount of illness except that evidence of ischaemia on the ECG was found in nine cases and one control. The cases did n...

Previous work has provided evidence of a role for the hippocampal formation in contextual as opposed to cue conditioning. Similar deficits have been observed after transection of the fimbria/fornix, part of which consists of the hippocampal-nucleus accumbens (N.Acc) connection arising from both the dorsal and ventral subiculum. By means of electrolytic lesions of the N.Acc, we showed that the s...

I N THE previous paper a technique for the determination of the electrolytic resistance of the blood clot was presented (I). The present paper deals with the variations in the electrolytic resistance of the blood clot over a 40. to &-hour period, and with the physiological significance of certain measurements of the resistance. The curve of the resistance against time will be called the electro...

appeared a report on Electrolytic Chlorogen by Captain W. Hodgkinson, r.e., and Mr. C. M. Hutchinson, c.i.ii., Imperial Agricultural Bacteriologist of the Agricultural Research Institute, Pusa. The principal objects of this enquiry, which were carried out under the auspices of the Army Department (Simla), were to determine the possibility of preparing in India from indigenous materials and by s...

x CHAPTER I GENERAL INTRODUCTION 1 Seizures in Man 1 Occurrence 1 Etiology 1 Animal Models of Convulsive Disorders 4 Seizure Models Based on Electrical Stimulation ... 5 Seizure Models Based on Chemical Stimulation .... 7 Seizure Models Based on Cortical Lesions 7 Seizure Models Based on Genetic Determinants .... 8 Putative Neuromediators in Seizure Activity 10 Catecholamines 10 5-Hydroxytrypta...