BACKGROUND To determine the cost-effectiveness of transversus abdominis plane block with liposomal bupivacaine (TAP) compared to oral opioids alone for acute postoperative pain after laparoscopic hysterectomy for early endometrial cancer. METHODS A cost-effectiveness analysis using a decision tree structure with a 30.5 day time-horizon was used to calculate incremental cost-effectiveness rati...

As a centerpiece of antigen processing, the ATP-binding cassette transporter associated with antigen processing (TAP) became a main target for viral immune evasion. The herpesviral ICP47 inhibits TAP function, thereby suppressing an adaptive immune response. Here, we report on a thermostable ICP47-TAP complex, generated by fusion of different ICP47 fragments. These fusion complexes allowed us t...

In 2000 and 2001 Canadians were shocked by water contamination events that took place in two provinces. In 2004 we undertook an internet-based survey across Canada that asked respondents to identify in percentage terms their total drinking water consumption according to one of three sources: tap water, bottled water, and home-filtered water (either some type of container or an in-tap filter dev...

A time of flight sensor has been equipped with a sensing wire parallel to the flow direction (flow parallel wire, FPW). A heat pulse is generated with a coil in the flow channel. The FPW has a center tap allowing its upstream and downstream parts to join in a half bridge. When a heat pulse passes the FPW, a large output peak is generated. The time between heat pulse generation and recording the...

  Objective: Considering the use of triple antibiotic paste (TAP) for root canal treatment of open apex teeth, this study aimed to assess the effect of TAP and calcium hydroxide (CH) on bond strength of composite to dentin.   Methods: This in-vitro study was conducted on 32 extracted human premolar teeth. After disinfection with 2% thymol solution, the enamel on the buccal surface of specimens ...

Human TAP is an orthologue of the yeast mRNA export factor Mex67p. In mammalian cells, TAP has a preferential intranuclear localization, but can also be detected at the nuclear pores and shuttles between the nucleus and the cytoplasm. TAP directly associates with mRNA in vivo, as it can be UV-crosslinked to poly(A)+ RNA in HeLa cells. Both the FG-repeat domain of nucleoporin CAN/Nup214 and a no...

Previously, we detected, by monoclonal antibody, three Moloney murine sarcoma virus (Mo-MSV)-activated intracellular transformation-associated proteins (TAP), (P66, P63, and P60) in several Mo-MSV-transformed rat cell lines (Chan et al., Biochem. Biophys. Res. Commun., 134: 1223-1230, 1986) and found the release of TAP into the extracellular medium with a change from three intracellular polypep...

The Tree Augmentation Problem (TAP) is: given a tree T = (V, E) and a set E of edges (called links) on V disjoint to E , find a minimum size edge subset F ⊆ E so that T +F is 2-edge-connected. TAP is equivalent to the problem of finding a minimum size edge-cover F ⊆ E of a laminar set-family. We consider the restriction LL-TAP of TAP to instances when every link in E connects two leaves of T . ...

BACKGROUND Leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, is used worldwide in premenopausal women with hormone receptor-positive breast cancer. This study was conducted to assess the non-inferiority of the 6-month depot formulation, TAP-144-SR (6M) 22.5 mg to the 3-month depot formulation, TAP-144-SR (3M) 11.25 mg in postoperative, premenopausal patients with hormone rec...