background: resistance to antiepileptic drugs as well as intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (dha), make it as a good candidate for designing and development of the new anticonvulsant medications. methods: ten dha-based...

introduction: nowadays, more than 10,000 different types of medical devices can be found in hospitals. this way, medical electrical equipment is being employed in a wide variety of fields in medical sciences with different physiological effects and measurements. hospitals and medical centers must ensure that their critical medical devices are safe, accurate, reliable and operational at the requ...

A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our resul...

Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied using actophotometer and anticonvulsant effect wa...

DESPITE the high incidence of convulsive disorders and widespread use of shock therapy in the major psychoses, relatively few investigations have dealt with the physiological properties of experimental seizures (1, 2, 3, 10, 12, 14, 16, 17). Convulsive threshold has received considerable attention, particularly in the testing of anticonvulsant drugs (11, 13, 15, 18, 21, and others), but thresho...

April 1938. The patient with the shaved head is passively lying on a bed on the first floor of a room-laboratory of the Clinic of Nervous and Mental Diseases of the Royal University of Rome. Several electric shocks are administered under strict supervision of the medical team of Ugo Cerletti (1867-1963). After the treatment, his psychic conditions get somewhat better. The electroshock machine, ...

Aminophylline (50-100 mg/kg) and strychnine (0.125-0.5 mg/kg) significantly raised the ED50 values of LY 300164 against maximal electroshock in mice, from 4 to 8 mg/kg (aminophylline 100 mg/kg) and from 3.6 to 11.5 mg/kg (strychnine 0.5 mg/kg). Also, aminophylline (25-50 mg/kg) and strychnine (0.125-0.25 mg/kg) increased the ED50 value of lamotrigine in this test, for instance from 5.5 to 8.0 m...