purpose: the aim of this study was to test the in vitro sensitivity of lymphocytes of patients with head and neck cancer against gamma irradiation and also to find out if the frequencies of chromosomal aberrations correlate with side effects of radiotherapy. patients and methods : peripheral blood of 101 patients with head and neck cancer was collected before the onset of radiotherapy, cultured...

Alzheimer hastalığı (AH) öncelikli olarak yaşlı popülasyonda görülen, klinik bellek ve bilişsel bozukluklar ile karakterize, ilerleyici nörodejeneratif bir hastalıktır. 
 Hastalığın etiyolojisinin henüz tam belirlenememiş olması, hasta popülasyonunun yıllar geçtikçe artması, radikal tedavinin olmayışı, tedavi bakım maliyetinin oldukça yüksek hastaların yaşam kalitesini düşürmesi gibi sebep...

Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder, characterized by β-amyloid plaques, neurofibrillary tangles loss of cholinergic neurons. Butyrylcholinesterase (BChE) inhibition one the most critical strategy for treatment AD since BChE causes inactivation neurotransmitter acetylcholine has positive effects on promoting formation fibrils. Our previous stud...

organophosphate chronic toxicity has been evaluated in this study. biological screening for organophosphate insecticide-exposed workers is mostly recommended for mixers, loaders, formulators and spraymen. we have studied 17 occupationally exposed persons to pesticides. using ellman's colorimetric method, their plasma cholinesterase activities have been measured. results show that the appea...

introduction: telomeric repeat amplification protocol assay (trap assay) is a standard established technique to detect the activity (expression) of telomerase in the cancerous samples. it includes a time-consuming procedure that has significant drawbacks such as high cost, complicacy, time-consuming procedure, equipment-dependent steps and false-positive signals caused by inclusion of pcr insid...

In this study, it was aimed to compare the antioxidant properties of extracts obtained from extraction olive leaves in Hatay province prepared with different solvents. For purpose, were extracted using pure methyl alcohol soxhlet and also by maceration 60% ethanol, 70% methanol, 90% acetone (v/v) distilled water. Total Flavonoid Content (TFC), Phenolic (TPC), Ferric Antioxidant Reducing Power (...

Novel acrylamide and methacryloyl carrying piperazine-dihydrofuran derivatives (3a-p) were designed obtained from radical cyclizations of unsaturated piperazine (1a-f) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)3. Obtained characterized spectroscopic methods. In vitro AChE inhibitory activites 3a-p evaluated against (Acetylcholinesterase) Ellman method test results showed that 3a, ...

In the current study, a number of alkaloids including retamine, cytisine, and sparteine (quinolizidine-type), yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type) were tested in vitro for their inhibitory act...