Thrombin exerts pleiotropic effects on endothelial cells, including the release of microparticles (EMPs) that disseminate and exchange information with vascular cells. Nevertheless, the mechanisms leading to their generation are not elucidated. We performed microarray analysis to identify genes involved in EMP release by the endothelial cell line HMEC-1 in response to thrombin. We identified a ...

Thrombin exerts pleiotropic effects on endothelial cells, including the release of microparticles (EMPs) that disseminate and exchange information with vascular cells. Nevertheless, the mechanisms leading to their generation are not elucidated. We performed microarray analysis to identify genes involved in EMP release by the endothelial cell line HMEC-1 in response to thrombin. We identified a ...

Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isolated from EC media and their ability to directly produce ROS was assessed by l...

NADPH regeneration is a limiting factor in reduction of xylose to xylitol in C. tropicalis. The oxidative PPP is the major source of NADPH biosynthesis in yeast. To enhance metabolic flux through PPP for promotion of NADPH regeneration. Genes involoved in EMP pathway were engineered by sequencial disruption and over-expression. For this, several genes involves in EMP pathway and promoters were ...

PURPOSE The purpose is to determine a safe weekly dose of i.v. estramustine phosphate (EMP) to combine with weekly paclitaxel and monthly carboplatin in patients with advanced prostate cancer. EXPERIMENTAL DESIGN Patients with advanced prostate cancer (castrate and noncastrate) were administered escalating doses of weekly 1-h infusion of i.v. EMP (500-1000-1500 mg/m(2)) in combination with we...

Extramedullary plasmacytoma (EMP) of the orbit is an extremely rare tumor, which frequently manifests with nonspecific symptoms. In the case reported, the symptoms of relapsing dacryocystitis appeared before the diagnosis of orbital EMP in a 60-year-old man. Moreover, EMP of the right submandibular gland that had been excised and treated by radiotherapy preceded the orbital lesion by seven year...

Current evidence suggests that regenerative v. degenerative endothelial responses can be integrated in a clinical endothelial phenotype, reflecting the net result between damage from risk factors and endogenous repair capacity. We have previously shown that a cocoa flavanol (CF) intervention can improve endothelial function and increase the regenerative capacity of the endothelium by mobilising...

AIMS Endothelial microparticles (EMP) are complex vesicular structures shed from activated or apoptotic endothelial cells. As endurance exercise affects the endothelium, the objective of the study was to examine levels of EMP and angiogenic growth factors following different endurance exercise protocols. METHODS 12 subjects performed 3 different endurance exercise protocols: 1. High volume tr...

C-Met is a receptor tyrosine kinase that overexpressed in range of different cancer types, and has been identified as potential biomarker for imaging therapy. Previously, 68Ga-labelled peptide, [68Ga]Ga-EMP-100, shown promise c-Met renal cell carcinoma humans. Herein, we report the synthesis preliminary biological evaluation an [18F]AlF-labelled analogue, [18F]AlF-EMP-105, by positron emission ...

Model-driven development nowadays often is done using the tools from the Eclipse Modeling Project (EMP). We developed a number of meta-models and transformations to support a model-driven user interface development within EMP. This paper presents our Swing and XUL meta-models and demonstrates what they can be used for. Author