A positively charged chiral stationary phase (CSP) was prepared by chemically immobilizing cellulose 3,5-dimethylphenylcarbamate onto methacryloyldiethylenetriaminopropylated silica (MCDEAPS) via a radical copolymerization reaction. The prepared CSP was evaluated for enantiomer separation in nonaqueous capillary electrochromatography (CEC). Electroosmotic flow (EOF) generated on the prepared CS...

of amino alcohols using Z-L-Glu-L-Pro or Z-L-Glu-D-Pro as chiral counter ions and Hypercarb as the solid phase. Chirality 9: 650}655. Knox JH and Jurand J (1982) Separation of optical isomers by zwitterion pair chromatography. Journal of Chromatography 234: 222}224. Knox JH and Ross P (1997) Carbon-based packing materials for liquid chromatography. Advances in Chromatography, 74}162. Petterson ...

The single handedness of biological molecules has fascinated scientists and laymen alike since Pasteur's first painstaking separation of the enantiomorphic crystals of a tartrate salt over 150 years ago. More recently, a number of theoretical and experimental investigations have helped to delineate models for how one enantiomer might have come to dominate over the other from what presumably was...

The enantiomers of metalaxyl acid metabolite (MX-acid) were separated by HPLC using cellulose-tris-(3,5-dimethylphenyl-carbamate) (CDMPC) as chiral stationary phase. The effects of mobile phase composition, flow rate and column temperature on the resolution were investigated and good separation was achieved with n-hexane/2-propanol/trifluoroacetic acid as mobile phase. The circular dichroisms d...

A series of chiral aryl amide compounds bearing peptide pendants have been investigated as low molecular weight gelators. A mechanistic study reveals that complementary hydrogen bonding from peptide pendants is the main driving force for the formation of organogels. This new class of organogels can exhibit multi-stimuli-responsive behavior upon applying (1) thermal, (2) pH, (3) enantiomeric pur...

Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains. This review exemplifies the various studies made to investigate the effect of chirality on the antiretroviral activity of top HIV-1 NNRTI compounds, s...

Herein we present the synthesis of the anhydrophytosphingosine jaspine B and three of its stereoisomers using a carbohydrate-derived alkoxyallene in order to obtain the products in enantiopure form. Key step of the reaction sequence is the addition of the lithiated alkoxyallene to pentadecanal, setting the configuration at the later C-2 of the ring system. This reaction step proceeds with moder...

Enantiomer separation represents an important topic especially in pharmaceutical and environmental fields where many drugs and pesticides are racemic compounds. In some cases, only one of the enantiomers has pharmacological or pesticidal activity while the other may exhibit antagonistic activities, unwanted side effects or even toxic effects. Therefore, the development of new enantioseparation ...

mefloquine (mfq), as a racemic mixture is used for the prophylaxis and treatment of malaria. stereoselective pharmacodynamic and pharmacokinetic differences have been observed for mfq. in the present study, the human blood was spiked with racemic mfq. the concentration of mfq enantiomers in various blood fractions including packed erythrocyte layer, platelet rich plasma and platelet poor plasma...

The (R)-enantiomer of racemic albuterol produces bronchodilation, whereas the (S)-enantiomer may increase airway reactivity. After oral or intravenous administration of racemic albuterol, the (R)- enantiomer is metabolized several times faster than the (S)-enantiomer; however, enantiomer disposition after inhaling racemic albuterol with a metered-dose inhaler (MDI) is not known. Accordingly, 10...