In mice affected with equine encephalomyelitis, the first pathological disturbance in infant animals is an inflammatory reaction, which is usually less pronounced in adult animals. A characteristic type of parenchymal damage appears to be independent of the inflammation. In such foci of injury there is initially a vacuolation of intercellular tissue. Neurones in such areas are at first intact, ...

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...

In the article by Jiménez-Ruiz et al., entitled “Neuro-logic manifestations of COVID-19”,1 it was concluded that “we must bear in mind infectious and non-infec-tious complications affect nervous system such as encephalitis, seizures, Guillain-Barre syndrome, dis-seminated encephalomyelitis hemorrhagic leuko-encephalitis, which are disorders can occur during or after viral infections.

Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) disease are two demyelinating diseases of the central nervous system (CNS) that serve as animal models for multiple sclerosis. Th1 cells are thought to play a role in the pathogenesis of CNS demyelination in both these diseases. We show here the differential influence of interleukin 12, a critical ...

The leader (L) peptide is located in the amino-terminal part of the polyprotein of members of the Cardiovirus (which includes Theiler's murine encephalomyelitis virus) and Aphthovirus genera of picornaviruses. Although the function of L is unknown, strain DA of Theiler's murine encephalomyelitis virus with a mutation of L produces a cell-specific restricted infection. We now report that the DA ...

abstract acute disseminated encephalomyelitis (adem) is a rare immune mediated and demyelinating disease of the central nervous system that usually affects children. it as a monophasic disorder related with multifocal neurologic symptoms. here in this paper we report seven cases of adem in pediatrics and besides a review of literatures are presented.