To clarify the endemic status of Chlamydia pneumoniae in Korea, the incidence of antibodies in 564 serum samples from healthy individuals, patients with respiratory infection, and cord blood specimens was evaluated. We conclude that C. pneumoniae infection is highly endemic in Korea and that this infection is associated with acute respiratory diseases.

Although most epidemic human infectious diseases are caused by recently introduced pathogens, cospeciation of parasite and host is commonplace for endemic infections. Occasional host infidelity, however, provides the endemic parasite with an opportunity to survive the potential extinction of its host. Such infidelity may account for the survival of certain types of human lice, and it is current...

background: cutaneous leishmaniasis (cl) is a major health problem in many parts of iran, although diagnosis of cl especially in the endemic area is easy, but treatment and management of the disease is a global dilemma. diag-nosis of cl in non-endemic area is not as simple as in endemic foci. in this study, the status and the proportions of cl induced by leishmania major and l. tropica among cl...

American cutaneous leishmaniasis (ACL) is an endemic disease in northern Paraná State, where it affects humans and dogs. This study aimed to verify the occurrence of the canine disease in ACL endemic areas. From September 1999 to July 2002, dogs were investigated in 7 rural areas of 5 municipalities where autochthonous human cases of ACL had been reported. Parasitological and serological method...

This viewpoint outlines the case for developing new chemical entities (NCEs) as racemates in infectious diseases and where both enantiomers racemate retain similar on- off-target activities well PK profiles. There are not major regulatory impediments development of a racemic drug, minimizing manufacturing costs becomes particularly important objective when bringing an anti-infective therapeutic...

In this paper we the study of dynamics time since infection structured vector born model with direct transmission. We use standard incidence term to new infections. analyze corresponding system partial differential equation and obtain an explicit formula for basic reproduction number ℜ 0 . The diseases-free equilibrium is locally globally asymptotically stable whenever less than one, < 1. En...

Healthy carriers of severe Hemoglobinopathies are usually asymptomatic and only efficiently detected through screening campaigns. Based upon epidemiological data, screenings have been offered for decades to populations of endemic Southern Europe for primary prevention of Thalassemia Major, while for many populations of the highly endemic African and Asian countries prevention for Sickle Cell Di...

Nos últimos anos, com o progressivo aumento dos casos de síndrome da imonodeficiência adquirida (AIDS) no Brasil, aumentou-se o interesse, por parte dos infectologistas e dos pesquisadores em doenças tropicais, pela interação entre as doenças endêmicas prevalentes em nosso país e a imunossupressão induzida pelo vírus da im unodeficiência humana (HIV). Embora, o impacto desta interação ainda sej...

Most emerging infectious diseases today, such as West Nile virus and sudden acute respiratory distress syndrome (SARS), arise from zoonotic reservoirs and many are transmitted by arthropod vectors. Ticks are among the most competent and versatile arthropod vectors of infectious diseases because ticks of all ages and both sexes remain infectious for generations without having to reacquire infect...

This comment addresses the inadequacies of research and development for diseases endemic in developing countries and explores how the patent system can inhibit innovation for new drugs for neglected diseases. The author analyzes four strategies to encourage innovation, including open source initiatives, patent pools, prizes, and wild card patent extensions, and examines how these alternative sy...