The brain sigma-1 receptors can bind neurosteroids and psychotropic drugs, including neuroleptics and cocaine and are implicated in schizophrenia, depression, and drug dependence. In this study, we found that sigma-1 receptors specifically target lipid storage sites (lipid droplets) on the endoplasmic reticulum by forming a distinct class of lipid microdomains. Both endogenously expressing sigm...

Some nuclear envelope proteins are localised to both the nuclear envelope and the endoplasmic reticulum; therefore, it seems plausible that even small amounts of these proteins can influence the organisation of the endoplasmic reticulum. A simple method to study the possible effects of nuclear envelope proteins on endoplasmic reticulum organisation is to analyze nuclear envelope protein overexp...

In the course of electron microscopic studies on the snake kidney, an unusual arrangement of the aganular endoplasmic reticulum was observed. Although it has been reported that the endoplasmic reticulum exhibits some peculiar arrangements in some kinds of cells (YAMADA 1958, YAMADA et al. 1958, PORTER et al. 1960, ISHIKAWA 1963, YAMAMOTO 1966), the present paper deals with the new type of arran...

endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway.  unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...

To characterize the Ca2+-transport properties of the plasma membrane and of the endoplasmic reticulum of bovine pulmonary artery, membrane vesicles are subfractionated by a procedure of density-gradient centrifugation that takes advantage of the selective effect of digitonin on the density of plasma-membrane vesicles. The obtained endoplasmic-reticulum fraction contains hardly any plasma-membra...

A Retraction of the Original Research article “Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis Endoplasmic Reticulum”Ye M, Qiu H, Cao Y, Zhang Mi Yu J, Wang C. Curcumin Reticulum. Front Pharmacol. 2017 Mar 21;8:148. doi: 10.3389/fphar.2017.00148.Following publication, concerns were raised regarding integrity images pub...

Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition. Additionally, cellular stress is accompanied by endoplasmic reticulum-stress which induces an unfolded protein response. It is unknown if epithelial-mesenchymal transition and endoplasmic reticulum-stress are ...

NR4A1 (Nur77, TR3) is an orphan nuclear receptor that is overexpressed in pancreatic cancer and exhibits prooncogenic activity. RNA interference of NR4A1 expression in Panc-1 cells induced apoptosis and subsequent proteomic analysis revealed the induction of several markers of endoplasmic reticulum stress, including glucoserelated protein 78 (GRP78), CCAAT/enhancer-binding protein-homologous pr...