BACKGROUND Sucrose is an effective analgesic for procedural pain in preterm infants. It has been hypothesized that its analgesic effects are mediated by the release of endogenous opioid neurotransmitters such as beta-endorphin. OBJECTIVE To determine whether intraoral administration of sucrose was associated with an increase in serum beta-endorphin concentrations in preterm infants with a ges...

Opioid peptides have been localized in a variety of peripheral tissues like placenta, thyroid, pancreas, gastrointestinal tract, in the reproductive tract of male and female and in the testes of rats. Immunoassayable material was detected in extracts of gonads, reproductive tract and accessory reproductive organs. Studies with naloxone have suggested that beta-endorphin may have an important ro...

Two separate lines of evidence suggested the present study. First, intracerebroventricularly (i.c.v.) administered morphine (a μ-opioid receptor agonist) and β-endorphin (an ε-opioid receptor agonist) produce antinociception by activating different descending pain inhibitory systems. Second, γ-irradiation attenuates the acute antinociceptive action of i.c.v. injected morphine, but not DPLPE (a ...

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Background: Wet cupping therapy is a complementary therapy in pain management. The mechanism of this therapy, however, needs further elucidation. Cells injured by wet cupping therapy seem to stimulate the expression of heat shock protein 70 (HSP70). Its benefit in pain reduction could be mediated by the expression of ß-endorphin. This study aimed at determining the correlation between HSP70 and...

Setiap ibu hamil trimester III akan mengalami perubahan fisiologis yang meliputi fisik dan psikologis. Salah satu terjadi pada adalah nyeri punggung menimbulkan ketidaknyamanan selama kehamilan. Endorphin massage yaitu teknik sentuhan atau pijatan ringan dapat memberikan rasa tenang nyaman memiliki kehamilan tua menjelang persalinan (Diana, 2019). Penelitian inii bertujuan untuk mengetahui kelu...

19 Cynanchi Wilfordii Radix (baishouwu), a medicinal herb, has been widely used in Asia to 20 treat a variety of diseases or illnesses. Cynandione A isolated from C. Wilfordii is the 21 principle acetophenone and exhibits neuroprotective and anti-inflammatory activities. This 22 study aims to evaluate the antihypersensitivity activities of cynandione A in neuropathy and 23 explored its mechanis...

The post-translational processing of pro-opiomelanocortin (POMC) in brain remains controversial. Classically, there was thought to be a single cell group in the arcuate nucleus with long projections through limbic structures. More recently, a second cell group was discovered in the caudal medulla. This study addresses the question of POMC processing in this region. Steady-state analysis of acid...

background: the present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones. methods: food was withdrawn 48 h prior to performing the formalin test, but water continued to be ava...