Introduction Necrotising enterocolitis (NEC) is a disease of the infant gastrointestinal tract (GIT) most commonly found in premature newborns. Although the aetiology and pathogenesis of the disease is not fully understood, in its most severe cases, NEC rapidly progresses from bacterial invasion of the intestinal wall to full-thickness bowel necrosis, leading to perforation and subsequent perit...

Necrotizing enterocolitis is the most common gastrointestinal emergency in neonates. The etiology is considered multifactorial. Risk factors include prematurity, enteral feeding, hypoxia, and bacterial colonization. The etiologic role of viruses is unclear. We present a case of necrotizing enterocolitis associated with cytomegalovirus and Proteobacteria in a 48-day-old, ex-premature infant and ...

matory response of the immature intestinal immune system, resulting in rapidly evolving intestinal gangrene, perforation, sepsis, shock and death [1, 2, 4] . Probiotics have been shown to be able to modify both the intestinal microbiota as well as the intestinal immune response. On this background, several clinical trials have been carried out in order to investigate the potential role of probi...

It is estimated that nearly 12% of infants born weighing less than 1500 g will develop NEC and about 30% of these infants will not survive. [4] More than 85% of all NEC cases occur in infants of very low birth weight or in very premature infants. [5]Full-term and near-term infants also develop the disease. Patent ductus arteriosus is a risk factor in premature babies, especially if conservative...

It is estimated that nearly 12% of infants born weighing less than 1500 g will develop NEC and about 30% of these infants will not survive. [4] More than 85% of all NEC cases occur in infants of very low birth weight or in very premature infants. [5]Full-term and near-term infants also develop the disease. Patent ductus arteriosus is a risk factor in premature babies, especially if conservative...

EDITORIAL SYNOPSIS Ischaemic enterocolitis is often incorrectly called fulminant ulcerative colitis at necropsy and this paper sets out the evidence on which a correct diagnosis may be made. The condition may be precipitated by an episode of hypotension in a patient with some degree of bowel ischaemia, producing sudden hypoxia. Such hypotension imitating the disease reaction may be due to a var...

Symptomatic nontyphoid salmonella enterocolitis patients were treated with tosufloxacin (TFLX) at oral doses of 150 mg three times a day for 5 to 7 days, but bacterial relapse without symptoms occurred in 85% of the patients within 15 days after the cessation of therapy. Our study indicates that TFLX may not be an ideal drug against symptomatic salmonella enterocolitis from a bacteriological po...

Genetically susceptible Lewis rats injected in the intestinal wall with peptidoglycan-polysaccharide (PG-APS) polymers develop chronic granulomatous enterocolitis concomitant with activation of the kallikrein-kinin system. To elucidate the role of high-molecular-weight kininogen (HK) in chronic enterocolitis, we back crossed Brown-Norway rats having a HK deficiency with Lewis rats for five gene...

Neutropenic enterocolitis is a severe and potentially life-threatening complication that may affect patients undergoing chemotherapy for acute leukemia or lymphoma. These patients may develop systemic sepsis through bacterial or fungal translocation across the intestinal wall. In many cases neutropenic enterocolitis is confined to the cecum, but the entire colon is sometimes involved. Most pati...

background: necrotizing enterocolitis (nec) is one of the most destructive diseases associated with conditions of neonatal prematurity. supplementation with enteral prebiotics may reduce the incidence of nec, especially in infants who fed exclusively with breast-milk. therefore, we compared the efficacy and safety of enteral supplementation of a prebiotic mixture (short chain galacto-oligosacch...