Oxidative damage caused by free radicals plays an important role in the causation and progression of many diseases, including aging. Free-radical damage is countered by many mechanisms, including both active antioxidant enzymatic activity in our body and passive antioxidants. Antioxidant response of our body can accommodate increased oxidative damage in diseased states to a level but beyond tha...

The concepts of oxidative stress and antioxidants have been implicated in neurodegenerative disorders. Oxidative stress was assessed by estimating lipid peroxidation product in the form of thiobarbituric acid reactive substances (TBARS). Enzymatic antioxidants like superoxide dismutase(SOD), glutathione peroxidase(GPx), catalase, ceruloplasmin and non enzymatic antioxidant vitamins like vitamin...

In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment and preservation. However, standard in vitro culture (IVC) conditions usually increase reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic development. It is well-known that higher than physiological levels of ROS trigger granulosa cell apo...

infertility is one of the most stressful conditions amongst married couples. male factor infertility is implicated in almost half of these cases. recent advances in the field of reproductive medicine have focused the attention of many researchers to consider reactive oxygen species (ros) as one of the mediators of infertility causing sperm dysfunction. although, ros is involved in many physiolo...

Iron nanoparticles (Fe NPs) have a wide array of biological and medical applications. In agriculture, Fe NPs has the potential to be used as an innovative technique alleviate deficiency in various crops, such grape. However, effect on alleviating stresses grapevine are unexplored. The aim this study was evaluate efficiency protecting ‘Asgari’ seedless grape (Vitis vinifera L.) against oxidative...

BACKGROUND Bael (Aegle marmelos (L.) Corr.) has been widely used in indigenous systems of Indian medicine to exploit its medicinal properties including astringent, antidiarrheal, antidysenteric, demulcent, antipyretic, antiulcer, anti-inflammatory and anti cancer activities. The present study aims to evaluate the antioxidative and antiulcer effect of methanolic extract of unripe fruit of Aegle ...

Patients with diabetes mellitus are likely to develop certain complication such as retinopathy, nephropathy and neuropathy as a result of oxidative stress and overwhelming free radicals. Treatment of diabetic patients with antioxidant may be of advantage in attenuating these complications. Oleuropein, the active constituent of olive leaf (Olea europaea), has been endowed with many beneficial an...

To evaluate the cholesterol lowering potential and protective ability of aqueous extract of Monodora myristica experimental hypercholesterolemic rats, a short-term study was conducted. Hypercholesterolemia was induced by administering cholesterol orally at a dose of 40 mg/kg/0.3 ml. Plant extracts 100 or 200 mg/kg body weight and Questran 0.26 g/kg were administered five times a week for eight ...

The present study was designed to evaluate the effect of Polyherbal formulation (250 mg/kg and 500 mg/kg body weight) on Isoprenaline hydrochloride induced myocardial necrosis in experimental rats. The herbal formulation that was prepared has synergistic effect and will reduce the toxicity of individual herbs. Isoprenaline hydrochloride (IPH) induced myocardial infarction was confirmed by distu...

Prime focus of the present investigation was to evaluate hepatoprotective potency of Ocimum sanctum (O. sanctum) aqueous extract against butyl p-hydroxybenzoic acid (butylparaben) toxicity in mice. Oral treatment of butylparaben (1320 mg/kg b.w./day) to mice for 30 days resulted in significant (p < 0.05) elevation in hepatic lipid peroxidation, which could be due to significant (p < 0.05) reduc...