Catalytic antibodies or abzymes as we have termed them have generated an avalanche of "forecasts and predictions" concerning their future applications. This, because in principle their only limitations are the designer's creativity and one's ability to access the entire immune systems repertoire. Keeping these so-called predictions in mind, we have sought out a truly formidable test for our de ...

The renin–angiotensin–aldosterone system is the well established endocrine system having significant role in preserving hemodynamic stability. Renin is secreted from the juxtaglomerular cells of the kidney. Phenylpiperazine derivatives have been reported as human renin inhibitor. To perform predictive QSAR modeling for 27 phenylpiperazine derivatives as renin enzyme inhibitors. The IC50 values ...