Congenital heart defects affect almost 1% of human newborns. Recently, mutations in Notch ligands and receptors have been found to cause a variety of heart defects in rodents and humans. However, the molecular effects downstream of Notch are still poorly understood. Here we report that combined inactivation of Hey1 and HeyL, two primary target genes of Notch, causes severe heart malformations, ...

Background Colorectal liver metastases (CRLM) can be encased in a fibrous capsule separating cancer from normal tissue, which correlates with increased patient survival. This study elucidates cellular and molecular mechanisms of formation the possible role epithelial mesenchymal transition (EMT).