To examine whether sarcoid epithelioid cells of granulomatous lesions produce colony-stimulating factor (CSF), a growth factor of monocyte-macrophage series, the primary culture of sarcoid epithelioid cells was carried out from 16 biopsied lymph nodes which contained sarcoid granulomas, CSF activity was demonstrated at high titer in the conditioned media from all the epithelioid cell cultures. ...

UNLABELLED Epithelioid sarcoma is a rare neoplasm uniquely comprised of cells exhibiting both mesenchymal and epithelial features. Having propensity for local and distant recurrence, it poses a diagnostic dilemma secondary to pathologic complexity. Patients have dismal prognosis due to lack of effective therapy. HDAC inhibitors (HDACi) exhibit marked antitumor effects in various malignancies. T...

Proximal-type epithelioid sarcoma is an aggressive variant of epithelioid sarcoma most often occurring in soft tissues of the proximal limbs, characterized by polygonal cells, marked nuclear atypia, and varied rhabdoid features. Malignant rhabdoid tumor is an aggressive, well characterized entity typically with rhabdoid morphology and involving the kidney of pediatric patients. Rarely, tumors w...

Cutaneous epithelioid angiomatous nodule (CEAN) is a rare benign vascular proliferation recently described by Brenn and Fletcher.1 It typically develops in adults as a solitary, small, reddish, fast-growing nodular lesion most frequently located on the trunk or limbs.2 Histologically it consists of an infiltration of epithelioid cells, with abundant eosinophilic cytoplasm and vesicular nuclei w...

INTRODUCTION Epithelioid hemangioendothelioma is a rare vascular tumor that has an epithelioid and histiocytoid appearance, originates from vascular endothelial or pre-endothelial cells and comprises less than 1% of all vascular tumors. It was described for the first time in 1975 as pulmonary epithelioid hemangioendothelioma, because initially it was believed to be an aggressive form of broncho...

Cytokeratin expression has been documented in a variety of sarcomas including synovial sarcomas, epithelioid sarcomas, Ewing's sarcomas and, rarely, osteosarcomas. In osteosarcomas immunohistochemically shown to expression cytokeratins, a component of epithelioid cells is generally present. These epithelioid cytokeratin positive cells raise the possibility of metastatic disease with prognostic ...