نتایج جستجو برای: eskape pathogens
تعداد نتایج: 69386 فیلتر نتایج به سال:
Objectives: The bacteria in the ‘ESKAPE’ group are monitored due to their ability resist antibiotic action. During COVID-19 pandemic at our hospital, usage of meropenem and levofloxacin as empirical treatment for bacterial pneumonia increased might have contributed antimicrobial resistance problem. In this study, we evaluated ESKAPE infection rates susceptibility antibiotics Dr. Sardjito Hospit...
Bacterial survival requires an intact peptidoglycan layer, a three-dimensional exoskeleton that encapsulates the cytoplasmic membrane. Historically, the final steps of peptidoglycan synthesis are known to be carried out by D,D-transpeptidases, enzymes that are inhibited by the β-lactams, which constitute >50% of all antibacterials in clinical use. Here, we show that the carbapenem subclass of β...
Antimicrobial resistance and the shortage of novel antibiotics have led to an urgent need for new antibacterial drug leads. Several existing natural product scaffolds (including chelocardins) have not been developed because their suboptimal pharmacological properties could not be addressed at the time. It is demonstrated here that reviving such compounds through the application of biosynthetic ...
Multidrug-resistant (MDR) bacteria have become a severe threat to community wellbeing. Conventional antibiotics are getting progressively more ineffective as a consequence of resistance, making it imperative to realize improved antimicrobial options. In this review we emphasized the microorganisms primarily reported of being resistance, referred as ESKAPE pathogens (Enterococcus faecium, Staphy...
Abstract The rise in multidrug-resistant bacteria defines the need for identification of new antibacterial agents that are less prone to resistance acquisition. Compounds simultaneously inhibit multiple bacterial targets more likely suppress evolution target-based than monotargeting compounds. structurally similar ATP binding sites DNA gyrase and topoisomerase Ⅳ offer an opportunity accomplish ...
This study aimed to evaluate the antibacterial activity of microorganisms isolated before and during cocoa fermentation against ESKAPE pathogens. Microorganisms from process were on selective media tested Total titratable acidity, minimal inhibitory concentration (MIC) bactericidal (MBC) cell-free supernatant lactic acid bacteria (LAB) determined. The presence bacteriocin LAB was identified thr...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید