CONTEXT Impairment of esophageal motility is a common finding in patients with gastroesophageal reflux disease (GERD) as reduced lower esophageal sphincter (LES) basal pressure. A very low LES pressure might facilitate the occurrence of more gastroesophageal reflux whereas abnormal esophageal peristalsis may contribute to impaired esophageal clearance after reflux. OBJECTIVE Evaluate the esop...

Laryngopharyngeal reflux (LPR) and gastro-esophageal reflux disease (GERD) are different disorders. The term LPR is used to describe the acid in the stomach that comes up into the throat at the level of the laryngopharnyx. LPR causes irritation and changes in the larynx. GERD is cause by the backflow of gastric contents into the esophagus, which leads to tissue damage or esophagitis and heartburn.

BACKGROUND Gastroesophageal reflux disease (GERD) is the most prevalent acid-related disorder in Canada and is associated with significant impairment of health-related quality of life. Since the last Canadian Consensus Conference in 1996, GERD management has evolved substantially. OBJECTIVE To develop up-to-date evidence-based recommendations relevant to the needs of Canadian health care prov...

BACKGROUND Childhood-to-adult persistent asthma is usually considered to be an atopic disease. However gastroesophageal reflux may also play an important role in this phenotype of asthma, especially when it is refractory to pulmonary medicine. METHODS Fifty-seven consecutive GERD patients who had decades of childhood-to-adult persistent asthmatic symptoms refractory to pulmonary medication we...

Background/Aims Neurologically impaired patients frequently suffer from gastrointestinal tract problems, such as gastroesophageal reflux disease (GERD). In this study, we aimed to define the risk factors for GERD in neurologically impaired children. Methods From May 2006 to March 2014, 101 neurologically impaired children who received 24-hour esophageal pH monitoring at Severance Children's H...

The prevalence of GERD increases in asthmatics compared with normal controls. The prevalence of GERD in asthmatics is estimated at between 34% and 89%5,12-16, which probably reflects the variation in GERD definition and populations studied. Although a proportion of patients with GERD have no obvious symptoms, data showed that, among the asthmatics, 77%, 55%, and 24% experienced heartburn, regur...

Medical therapy remains the most popular treatment for gastroesophageal reflux disease (GERD). Whilst interest in drug development for GERD has declined over the last few years primarily due to the conversion of most proton pump inhibitor (PPI)'s to generic and over the counter compounds, there are still numerous areas of unmet needs in GERD. Drug development has been focused on potent histamin...

introduction: atrial arrhythmia is a common complication in patients with gastro esophageal reflux disease (gerd). the treatment of palpitation is relatively problematic in these patients, especially if there is not enough evidence of cardiovascular or systemic diseases. the esophagus is in close proximity to the left atrium posterior wall. hypothetically, locally released cytokines from esopha...

Introduction: Gastroesophageal reflux (GER) is the most common of esophageal disorder in all ages.  GER defined as passage of gastric contents into the esophagus, and GER disease (GERD), (symptoms or complications of GER), are common pediatric problems. Clinical manifestations of GERD in infants include regurgitation, irritability, choking, gagging vomiting, poor weight gain and respiratory dis...

The case presented here illustrates the possible complications of gastroesophageal reflux disease (GERD). In its simple form, GERD poses no expectation of extra mortality. However, certain histopathologic complications of GERD predispose to the development of esophageal adenocarcinoma. The clinical course, diagnosis, treatment, prognosis, and preventive surveillance of GERD and Barrett metaplas...