The idea that aging is a purposeful, programmed series of events is intuitively appealing based on its many conserved aspects and the demonstrated feasibility of modifying life span by manipulating single genes or pathways. Yet, the case for a nonadaptive basis of aging is strong and now all but generally accepted in the field. Here, we briefly review why the case for programmed aging is weak, ...

Programming languages serve a dual purpose: to communicate programs to computers, and to communicate programs to humans. Indeed, it is this dual purpose that makes programming language design a constrained and challenging problem. Inheritance is an essential aspect of that second purpose: it is a tool to improve communication. Humans understand new concepts most readily by first looking at a nu...

Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation, distinguished from rare variations by a requirement for the least abundant allele to have a frequency of 1% or more. A wide range of genetics disciplines stand to benefit greatly from the study and use of SNPs. The recent surge of interest in SNPs stems from, and continues to depend upon, the merging and coincident...

Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence a...

This paper presents a propositional version of Kit Fine’s (quantified) logic for essentialist statements, provides it with a semantics, and proves the former adequate (i.e. sound and complete) with respect to the latter.

The main subject of this study is to examine the possibility of discussing the divine essence in Ibn ‘Arabī‘s school of mysticism. The author of this article intends to investigate the possibility of the relative discussion of the divine essence. However, opposing theories such as ‘Allāmah Ṭabātabā’ī’s stance in Al-Rasā’il al-tawḥīdiyya favor the absolute impossibility of talking about the divi...

A perceptually motivated subspace based approach is proposed for enhancement of speech corrupted by colored noise. The proposed approach takes into account the frequency masking properties of the human auditory system and reduces the perceptual effect of the residual noise. Objective measures and informal listening tests demonstrated improvements over other subspace-based methods when tested wi...

Abstract Previous works have shown that time asymmetric forcing on one hand, as well as non-Gaussian noises on the other, can separately enhance the efficiency and current of a Brownian motor. Here, we study the result of subjecting a Brownian motor to both effects simultaneously. Our results have been compared with those obtained for the Gaussian white noise regime in the adiabatic limit. We f...