DNA polymerase eta is a Y family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous interaction between the PIP box in pol eta and PCNA and between the UBZ in pol eta and monoubiquitin attached to PCNA. Whereas monoubiquitination of PCNA is required for its interaction with pol eta during TLS, we now show that monoubiquitination of pol eta inhibits this ...

The characterization and localization of endothelin A (ETA) and endothelin B (ETB) receptors have been determined in tissue sections of the human atrioventricular conducting system, surrounding regions of atrial and ventricular myocardium, and the left ventricular free wall by use of radioligand binding, polymerase chain reaction, and in situ hybridization. Selective ETA (BQ123) and ETB (BQ3020...

This paper gives a partial desingularisation construction for hyperkähler quotients and a criterion for the surjectivity of an analogue of the Kirwan map to the cohomology of hyperkähler quotients. This criterion is applied to some linear actions on hyperkähler vector spaces.

Let E be a Banach lattice and let M be a norm-closed and Dedekind σ-complete ideal of E. If E contains a lattice-isometric copy of ∞ , then E/M contains such a copy as well, or M contains a lattice copy of ∞. This is one of the consequences of more general results presented in this paper. 1. Introduction. Let E be a locally solid linear lattice (Riesz space), for example , a Banach lattice, let...

Recent developments on the Tate or Eta pairing computation over hyperelliptic curves by Duursma–Lee and Barreto et al. have focused on degenerate divisors. We present efficient methods that work for general divisors to compute the Eta paring over divisor class groups of the hyperelliptic curves Hd : y2 = x p−x+d where p is an odd prime. On the curve Hd of genus 3, we provide two efficient metho...

We discuss the resolution of toroidal orbifolds. For the resulting smooth Calabi–Yau manifolds, we calculate the intersection ring and determine the divisor topologies. In a next step, the orientifold quotients are constructed.

OBJECTIVE Tumor necrosis factor (TNF) antagonists fall into 2 classes:etanercept (ETA) is a soluble TNF receptor, while infliximab (INF) and adalimumab (ADA) are monoclonal antibodies against TNF. All 3 drugs are effective in treating rheumatoid arthritis. However, these agents have been associated with an increased risk of granulomatous infections, such as tuberculosis and histoplasmosis. Seve...