6-carbethoxy-5-(3'-bromophenyl)-3-aryl-2-cyclohexenones 2a-j were obtained from the1-aryl-3-(3'-bromophenyl)-2-propene-1-ones 1a-j by micheal addition of ethyl acetoacetate, followed by internal claisen condensation. reaction of 2a-j with hydrazine hydrate afforded the corresponding 6-aryl-4-(3'-bromophenyl)-3-oxo-2,3a,4,5-tetrahydro-2h-indazoles 3a-j. the structures of newly syn...

Several compounds were evaluated in vitro as alternative electron sinks to ruminal methanogenesis. They were incubated with ruminal fluid, buffer mixture, and finely ground alfalfa hay for 24 h, at 0, 6, 12, and 18 mM initial concentrations. The propionate enhancer oxaloacetic acid, the butyrate enhancer beta-hydroxybutyrate, and the butyrate unsaturated analog 3-butenoic acid were ineffective ...

A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using  holmium chloride as catalyst. The reactions were performed under solvent free conditions with ultrasound irradiation as the energy source. The advantages of this protocol include the excellent yield, operational simplicity, short tim...

γ-aminobutiric acid (gaba), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, baclofen, which is a lipophilic derivative of gaba. because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. in this study baclofen was easily synthesize...

an efficient, mild and environmentally friendly method was reported for the synthesis of an efficient, mild and environmentally friendly method was reported for the synthesis of pyranopyroles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of catalytic amounts of methyl imidazolium hydrogen sulfate ([hmim][hso4]) as an efficient catalyst. these synth...

in the present study, an attempt has been made to synthesize 3-methyl-4-arylmethylene isoxazole-5(4h)-one derivatives through sonication of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives in the presence of imidazole as a novel and effective catalyst in aqueous media. this green reaction under ultrasound irradiation has advantageous compared to conventional procedur...

The investigations by Xath, Chitale, and Belavady (1) showed that when n-glucose1 and an equimolar amount of sodium acetoacetate is fed to germinating mung beans or injected into rats (a), the production of n-ascorbic acid is greater than with glucose alone. It was further observed (2) that a condensation product of glucose and acetoacetate (glucose cycloacetoacetate ethyl ester) can be easily ...

Water is a versatile solvent in many ways, and in this sense performing organic reactions in this medium is now of great interest. The one-pot reaction of ethyl acetoacetate or benzyl acetoacetate, with benzaldehydes and malononitrile to provide some novel 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates has been performed over nano MgO with high performance in water as a green solvent a...