in MCF-7 human cancer cell line using magneic PLGA nanoparticles, dextran coated particles and empty PLGA nanoparticles.. Figure 1: Scanning electron microscopy (SEM) of nanoparticles with TEM inset showing distribution of magnetite cores. A) PLGA nanoparticles; B) PLGA microparticles; C) Cellulose nanoparticles. Particles are uniform in size, spherical and have high amounts of encapsulated mag...

BACKGROUND AND PURPOSE Erythropoietin (EPO) has been demonstrated to possess significant neuroprotective effects in stroke. We determined if the nano-drug form of human recombinant EPO (PLGA-EPO nanoparticles [PLGA-EPO-NP]) can enhance neuroprotection at lower dosages versus human recombinant EPO (r-EPO). METHODS Established neonatal rat model of unilateral ischemic stroke was used to compare...

Therapeutic angiogenesis is a promising strategy for treating ischemia. The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration and tube formation, and plays the critical role in developmental angiogenesis. We developed poly(lactic-co-glycolic-acid) (PLGA)-based S1P-containing microparticles (PLGA-S1P), which are biodegradable and co...

Collagen meshes with large or small openings were prepared after selective removal of PLGA mesh from PLGA–collagen composite collagen-coated mesh. The collagen support human skin fibroblast adhesion and promote cell proliferation.

BACKGROUND Peptide based vaccines may suffer from limited stability and inefficient delivery to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). In order to overcome such limitations, several types of biodegradable nanoparticles (NPs) have been developed as carrier system for antigens. The present study describes for the first time the extensive biological characteri...

PURPOSE Poly(lactic-co-glycolic acid) (PLGA) is excellent as a scaffolding matrix due to feasibility of processing and tunable biodegradability, yet the virgin scaffolds lack osteoconduction and osteoinduction. In this study, nano-hydroxyapatite (nHA) was coated on the interior surfaces of PLGA scaffolds in order to facilitate in vivo bone defect restoration using biomimetic ceramics while keep...

We recently demonstrated by in vitro experiments that PLGA (poly D, L-lactide-co-glycolide) potentiates T helper 1 (Th1) immune responses induced by a peptide derived from the recombinant major outer membrane protein (rMOMP) of Chlamydia trachomatis, and may be a promising vaccine delivery system. Herein we evaluated the immune-potentiating potential of PLGA by encapsulating the full-length rMO...

Background: The innovative repair materials for the bones are still lacking. So, we synthesized a porous microsphere by using basic fibroblast growth factor (bFGF), polylactide-co-glycolide (PLGA), poly L-lactic acid (PLLA) and hydroxylapatite (HAP), and its biocompatibility with bone marrow mesenchymal stem cells (BM-MSCs) was investigated in vitro. Methods: A modified solvent extraction/evapo...

in this study, the folate decorated biodegradable poly (lactide-co-glycolide) (plga) nanoparticles were developed for tumor targeting of anticancer agents. due to the overexpression of the folate receptor on tumor surface, the folate has been efficiently employed as a targeting moiety for various anticancer agents to avoid their non-specific attacks on normal tissues and also to increase their ...

BACKGROUND Effective cancer chemotherapy remains an important issue in cancer treatment, and signal transducer and activator of transcription-3 (Stat3) activation leads to cellular resistance of anticancer agents. Polymers are ideal vectors to carry both chemotherapeutics and small interfering ribonucleic acid (siRNA) to enhance antitumor efficacy. In this paper, poly(lactic-co-glycolic acid) (...