Two new compounds containing the title diphosphono-polyoxometalate anion and diprotonated ethylenediamine (enH(2)) or piperazine (ppzH(2)) countercations have been hydrothermally synthesized and structurally characterized ((enH(2))(4)[Mo(7)O(16)(O(3)PCH(2)PO(3))(3)].7H(2)O, triclinic, P(-)1, Z = 2, a = 10.3455(7) A, b = 13.136(1) A, and c = 20.216(3) A, alpha = 93.247(6) degrees, beta = 96.434(...

OBJECTIVES This study evaluated the effects of azimilide dihydrochloride (AZ) on anti-tachycardia pacing (ATP) and shock-terminated events in patients with implantable cardioverter defibrillators (ICDs). BACKGROUND Animal studies have shown the effectiveness of AZ for therapy of supraventricular and ventricular tachycardia (VT). Azimilide dihydrochloride was investigated as adjunctive treatme...

OBJECTIVES To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus. METHODS A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial. After assessing for eligibility, 82 patients were randomly assigned into placebo or trimetazidine groups according to the medication. The trimetazidine g...

Zn(2+)-induced fluorescence enhancement of the TPEN (N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine)-based ligand, N,N-bis(1-isoquinolylmethyl)-N',N'-bis(pyridylmethyl)ethylenediamine (N,N-1-isoBQBPEN, 1b), has been investigated. Upon Zn(2+) binding, 1b shows a fluorescence increase (ϕZn = 0.028) at 353 and 475 nm. The fluorescence enhancement at longer wavelengths is due to intramolecular ...

Two bisquinoline derivatives, N,N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N,N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay....

A stability indicating High-Performance Liquid Chromatography (HPLC) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mMKH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method waslinear over the range of 1-20 μg/mL of ce...

Four new ethylenediamine-templated iron arsenates and fluoroarsenates have been hydrothermally synthesized from iron metal, hydrofluoric and arsenic acids, and ethylenediamine. Fe(H2AsO4)(HAsO4)2.enH2.H2O (1) is one-dimensional and contains chains, FeIIIFeIIF2(HAsO4)(AsO4).enH2.2H2O (2) is a layered fluoroarsenate, and Fe3(HAsO4)6.enH2.NH3.NH4 (3) and Fe2F2(AsO4)2(H2O).enH2 (4) are an arsenate ...

The cancer potencies of 3,3'-dimethylbenzidine (commonly called o-tolidine) and 3,3'dimethylbenzidine dihydrochloride were estimated from dose-response data for multiple treatment-responding tumor sites among male rats exposed orally to 3,3'-dimethylbenzidine dihydrochloride via drinking water (NTP, 1991). These sites included liver, lung, preputial gland, oral cavity, skin, small intestines, l...

AIM The present study was designed to investigate the effects of estradiol-ethylenediamine derivative on perfusion pressure and coronary resistance in rats. An additional aim was to identify the molecular mechanisms involved. METHODS The Langendorff model was used to measure perfusion pressure and coronary resistance changes in isolated rat heart after estradiol-ethylenediamine derivative alo...