BACKGROUND Endocrine-disrupting effects of phthalates are understood primarily from in utero exposures within the fetal rat testis. Nevertheless, their path of action, dose-response character, and cellular target(s) within the fetal testis are not known. OBJECTIVES In this study we investigated the effects of di-(2-ethylhexyl) phthalate (DEHP), mono-(2-ethylhexyl) phthalate (MEHP), and severa...

In this study, we were interested in the valuation of Ocimum gratissimum, an aromatic and medicinal plant Ivorian flora. The essential oils leafy branches gratissimum extracted by hydrodistillation with a Clévenger-type device. yield obtained increases from (0.05±0.01%) to (0.42±0.08%) depending on drying time. density is almost constant at 0.80. chemical composition was identified after analys...

OBJECTIVES The objective of this study was to evaluate the impact of phthalate exposure on pregnancy duration and birth outcomes based on the Polish Mother and Child Cohort (REPRO_PL). MATERIAL AND METHODS Phthalate exposure was determined by measuring 11 phthalate metabolites (mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthala...

Phthalates are multifunctional chemicals used in a wide variety of consumer products. The aim of this study was to investigate whether levels of urinary phthalate metabolites in urine samples of Austrian mothers and their children were associated with consumer habits and health indicators. Within an Austrian biomonitoring survey, urine samples from 50 mother-child pairs of five communities (two...

Background: Phthalates are widely used as plasticizers in polyethylene terephthalate (PET) products. Several pharmaceutical products have been stored in PET containers, and due to serious health effects of phthalates, migration levels of them into pharmaceutical products must be determined. In the present study, leaching levels of four common phthalate esters including di-n-butyl phthalate (DBP...

Phthalates are a group of plasticizers that are widely used in many consumer products and medical devices, thus generating a huge burden to human health. Phthalates have been known to cause a number of developmental and reproductive disorders functioning as endocrine modulators. They are also involved in carcinogenesis with mechanisms less understood. To further understand the molecular mechani...

Children are exposed to a wide range of chemicals in their everyday environments, including the preschool. In this study, we evaluated the levels of phthalates, non-phthalate plasticizers and bisphenols in dust from 100 Swedish preschools and identified important exposure factors in the indoor environment. In addition, children's total exposure to these chemicals was determined by urine analysi...

Using a novel and highly selective technique, we measured monoester metabolites of seven commonly used phthalates in urine samples from a reference population of 289 adult humans. This analytical approach allowed us to directly measure the individual phthalate metabolites responsible for the animal reproductive and developmental toxicity while avoiding contamination from the ubiquitous parent c...

It has become increasingly evident in recent years that the dialkyl phthalate esters are widely distributed in our environment (1-4). As an explanation of this wide distribution there are many possible pathways by which these chemicals can be introduced into the human body. Jaeger and Rubin (5) have shown that di-2-ethylhexyl phthalate (DEHP) can be found in the tissues of patients who have rec...

Dialkyl phthalate esters (DPEs) are widely used chemicals, with over 4 million tonnes being produced worldwide each year. On the basis of their octanol-water partition coefficients (Kow), which range from 10(1.61) for dimethyl phthalate to 10(9.46) for di-iso-decyl phthalate, certain phthalate esters have the potential to bioconcentrate and biomagnify in aquatic food webs. However, there are no...