BACKGROUND Human tissue kallikreins (KLKs) are a family of 15 trypsin-like or chymotrypsin-like secreted serine proteases (KLK1-KLK15). Multiple KLKs have been quantitatively identified in normal stratum corneum (SC) and sweat as candidate desquamation-related proteases. OBJECTIVES To quantify KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, KLK13 and KLK14 in the SC and serum of patients with psoriasis...

The clinical efficacy of retinoids in benign and malignant skin diseases involving immune mechanisms suggests that they affect the immunologic functions of the epidermis. However, these effects have yet to be demonstrated. The action of vitamin A (retinol) and the synthetic retinoids, isotretinoin, etretinate, acitretin, and arotinoid-free acid have been studied on the lymphocyte proliferation ...

Neonatal mouse keratinocytes cultured in low calcium (0.01 mmol/l) show rapid growth and little stratification when compared with cells grown in normal 1.2 mmol/l calcium. The effect of low calcium on the amount and synthesis of specific differentiation proteins was studied; additionally, the effect of 10(-8) mol/l triamcinolone acetonide, and 6 micrograms/ml of retinoic acid and of etretinate ...

-___ Abstract Human trials of cancer chemoprevention employing antitumor promoter retinoids are currently progressing worldwide and are targeting mainly skin, lung, uterine cervix or breast cancers. Although the inhibitory effects of various synthetic retinoids on experimental cancers and tumor-derived cell lines are promising, several problems with adverse effects such as mucocutaneous disorde...

A 78-year-old woman who had been suffering from psoriasis vulgaris for 31 years was admitted to hospital because of her erythroderma. A toxic eruption was suspected and she was treated with prednisolone 30 mg daily. However, it was ineffective and, suspecting psoriatic erythroderma, cyclosporine 150 mg daily was administered with tapering of the prednisolone. Two weeks after a dose reduction of...

1. van Osch LD, Oranje AP, Keukens FM, Voorst Vader van PC, Veldman E. Keratosis follicularis spinulosa decalvans: A family study of seven male cases and six female carriers. J Med Genet 1992;29:36-40. 2. Fong K, Wedgeworth EK, Lai-Cheong JE, Tosi I, Mellerio JE, Powell AM, et al. MBTPS2 mutation in a British pedigree with keratosis follicularis spinulosa decalvans. Clin Exp Dermatol 2012;37:63...

Sir, Bullous congenital ichthyosiform erythroderma (BCIE), or epidermolytic hyperkeratosis (MIM# 113.800), is a rare disorder of keratinization associated with blistering in its early phase. It was first described by Jean-Louis Brocq in 1902 as érythrodermie congénitale ichthyosiforme avec hyperépidermotrophie. Although most cases are sporadic, familial cases show an autosomal dominant pattern ...

The application of retinoic acid (RA) to the developing chick limb bud causes 6-digit double posterior limbs to form instead of the normal 3-digit limb. As an attempt to begin a molecular analysis of this phenomenon we have identified and characterized a soluble cytoplasmic receptor for RA, namely cytoplasmic retinoic acid-binding protein (CRABP), from the cells of the chick limb bud. It is pre...

The synt hetic retinoids represent a new class of drugs wh ich a re highly effective in t he treatment of a broad spectrum of dermatologic d isease, including cystic acne, psori asis, and cutaneous di sorders of keratinization [1 3]. Moreover, t he use of synthetic retinoids in cancer prevent ion and therapy fo r both cutaneous and in te rna l t umors is potent ially the most signi ficant clini...

Acitretin (Soriatane®, Neotigason®) is a synthetic retinoid for the treatment of severe forms of psoriasis and disorders of keratinisation. Like other retinoids, acitretin has a teratogenic potential since it affects cellular differentiation and proliferation. With the use of oral isotretinoin (Accutane®, Roaccutane®), malformations involving the central nervous system as well as craniofacial, ...