With increasing restrictions and safety protocols implemented in prescribing opioids, there has been an increased incidence of recreational abuse of over-thecounter medications, including loperamide. Loperamide is a peripherally-acting μ-opioid receptor agonist in the gastrointestinal tract which, if taken at high doses, can cross the blood-brain barrier to produce euphoria and analgesia effects.

Using estimated sentiment indices based on CBDC-related social media posts, and testing for the effects of regulatory-related announcements upon blockchain cryptocurrency-related funds, this research presents two key findings: first, continued evolution pricing structures digital finance products to respond such perceived threats constitutes a further evolutionary point in product's life-cycle....

In the late 1980s the National Science Foundation advanced a proposal to integrate researchers working in different disciplines around the United States in virtual laboratories. Inspired by the potential for physical networks like the Internet to support and foster collaboration, the emergence of these "collaboratories" was celebrated as heralding a new epoch in scientific collaboration, which ...

The agrarian crisis engulfing the country is bankrupting the farming communities. The euphoria that began with the green revolution, making India self-sufficient in food grains and increasing the incomes of farmers across the board, was eroded within a matter of decades, so plunging the agrarian economy into deep gloom. Facing low yields, spiraling costs of cultivation, a near stagnant technolo...

BACKGROUND In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, and subjective effects resembling endogenous psychoses. Studying the comparative and interactive effects of these agents may provide insights into the roles of the glutamate and monoamine systems in psychosis and cognition. OBJECTIVES To directly compare the effects of ketamine and...

The Stock Exchange is basically ruled by the extreme market sentiments of euphoria and fear. The type of sentiment is given by the color of the candlestick (white = bullish sentiments, black = bearish sentiments), meanwhile the intensity of the sentiment is given by the size of it. In this paper you will see that the intensity of any sentiment is astonishingly distributed in a robust, systemati...

This study investigates the internal and external strategic choices that telecommunications firms, operating in a dynamic network environment, make to adapt to changes and to respond quickly in order to create or to sustain their competitive advantage. In particular, in the European telecommunications industry incumbent firms have faced important challenges from new technologies, liberalization...

TO THE EDITOR: In the August issue of the Journal, Charles P. O’Brien, M.D., Ph.D. (1) stated the following about modafinil, a drug that he reported may decrease cocaine use in some cocaine users: “The medication has not been reported to produce euphoria, and there has been no indication of excessive use or abuse in clinical trials” (p. 1428). As the scientific basis for his comment, the author...

Secondary aneurysmal bone cyst in fibrous dysplasia is exceedingly rare, especially in the skull and particularly in the frontal bone. We present a case of aneurysmal bone cyst concomitant with fibrous dysplasia in the frontal bone in a 15-year-old male patient presenting with headache and euphoria with an uncharacteristic imaging appearance and treated successfully by total resection.