BACKGROUND The S-Caine peel (Zars, Inc., Salt Lake City, UT) is a novel eutectic lidocaine/tetracaine mixture that is applied as a cream, drying upon exposure to air to form a flexible film that can be peeled off easily. The patented formulation can be used to anesthetize the skin prior to a variety of cutaneous procedures. OBJECTIVE To examine the clinical efficacy of the S-Caine peel as a t...

BACKGROUND The optimal local anesthetic for myringotomies or the insertion of tympanostomy tubes in adults should be easy and rapid to use, be painless during application, provide good anesthesia, be reversible, be inexpensive, and not cause any long-term damage to the tympanic membrane (TM). OBJECTIVE To evaluate the histologic effects of topical anesthetic agents on the healing of the TM af...

ObjectiveThis study was performed to investigate the analgesic effects of lidocaine and lidocaine/tramadol combination in epidural anaesthesia in dromedary camels. DesignExperimental Study AnimalsEight healthy immature dromedary camels ProceduresThe camels were randomly designed in 2 equal groups. In group L: lidocaine 2% (0.22 mg/kg) and in group LT: a combination of lidocaine 2% (0.22 mg/kg) ...

In this study, solvent-cast polymeric films containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast prepared from two polymers, pectin and Eudragit® NE 30D, by drying the solution in a hot air oven at 70 ± 3 °C 10 h. Glycerin was used as plasticizer. Lidocaine aspirin form loaded into patches. The physicomechanical properties of characterized texture analy...

DTA analysis was used to investigate the solidification reactions of alloy A319 with either 12 or 136 ppm of Sr added. Strontium does not affect primary solidification of (Al) dendrites but modifies the kinetics of the (Al)–Si eutectic. The effects of Sr level and of cooling rate on the characteristic temperatures for the (Al)–Si and other eutectic reactions are described.

The survival of cultured L1210 cells exposed to bleomycin A2 (BLM A2) was markedly decreased by coincubation with the local anesthetic lidocaine. The potentiation occurred with concentrations of lidocaine that were nontoxic and was dependent upon both the concentration of lidocaine and BLM A2. A 1000-fold decrease in survival was seen with a 1-h exposure to 8 mM lidocaine and 10 microM BLM A2 c...

PURPOSE It has been reported that the addition of epinephrine and/or bicarbonate to local anesthetic enhances the depth of epidural blockade and that initial partial bolus injection results in greater caudal spread. We evaluated the anesthetic effects of lidocaine with epinephrine and/or bicarbonate injected into the epidural space by bolus or catheter injection. METHODS Forty-four patients u...

Lidocaine is a frequently administered anti-arrhythmic drug, particularly useful in emergency situations because of its rapid onset of action (1). Therapeutic drug monitoring of lidocaine is recommended because of its potent central nervous system toxicity. Moreover, lidocaine has been implicated in numerous accidental and homicidal deaths (2). Thus its chemical stability in patients’ specimens...

introduction: nowadays, spinal anesthesia is associated with few complications in many surgical practices especially the elective caesarean which is taken as a suitable replacement for general anesthesia. different drugs are used for spinal anesthesia. this study aims to compare lidocaine 5% in combination with meperidine 5% plus lidocaine 5% for spinal anesthesia in non-emergency cesarean pati...

conclusions lidocaine-meperidine-diltiazem gel provides significantly better pain control than lidocaine-diltiazem gel and lidocaine gel alone during transrectal ultrasound guided prostate biopsy and probe insertion. this mixture gel is safe, easy to administer and well accepted by patients. results the mean of visual analog pain scale was 4.5 in group a, 3.5 in group b, and 2.0 in group c duri...