In the present study proniosomal gel of clotrimazole was formulated by using lecithin, cholesterol as encapsulating agents, nonionic surfactants Span and Tween with different grades. Evaluation of proniosomal gels for pH, vesicle size analysis, encapsulation efficiency, drug diffusion profiles, exvivo skin permeation and ex-vivo drug deposition studies on guinea pig skin, irritation test on rab...

Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of the microemulsion. Various surfactants and cosurfactants were screened for their ability to emul...

In the present study, is to development of Azelnidipine (AZP) transdermal patches and to study the effect of Dimethyl sulfoxide (DMSO) on drug permeation through across the rat abdominal skin. The transdermal patches were prepared by solvent casting method using different amounts and combination of hydroxyl propyl methyl cellulose (HPMC E15), Ethyl cellulose (EC) and Eudragit RS100 (ERS). The d...

The present study deals with the formulation, characterization of Metronidazole loaded ethosomal gel for treating oral infection. system comprises 2-5% phospholipids, 20-50% ethanol, 10% propylene glycol, cholesterol and v/v aqueous phase. Cold method was applied to develop ethosome. prepared ethosome evaluated vesicle size, entrapment efficiency,The Optimized Ethosome formulation converted in ...

This work is focused on the ex vivo study of corneal permeation of two anti-inflammatory drugs: diclofenac, and flurbiprofen (as a model of hydrophilic and lipophilic drug, respectively) loaded to cyclodextrins or polymeric nanoparticles in order to determine differences in their corneal permeation against free drug or commercial eye drops. These studies were carried out in a corneal device des...

Among different topical drug delivery systems, nanoemulsions (NEs) are attractive due to enhanced skin permeation potential and minimum toxicity. Topical nanoemulgels (NEMGELs) contain both gelling agents NEs thus can enhance with sustained effects at the site of application. Oxybutynin (OXB) is an anti-muscarinic agent that administered orally treat hyperhidrosis but its systemic side may decr...

Abstract Background Melatonin (MEL) is a powerful antioxidant molecule with anti-androgenic property. A microemulsion (ME) system loaded MEL was designed for treatment of androgenic alopecia. Pseudo-ternary phase diagram constructed, and ME formulae were developed using coconut oil, Tween 80 PEG 400. In the present study, characterized evaluated droplet size, polydispersity index, zeta potentia...

Objective: The present research is aimed to design and optimize a liposomal gel formulation of salicylic acid (SA) for enhanced drug permeation, higher skin retention, sustained release delivery reduced side effects in the effective treatment foot corn. Methods: Formulation designing optimization SA-loaded liposomes was done by box-Behnken experimental using three-factor, three-level approach. ...

The aim of this research was to investigate the effect non-invasive dermal electroporation (EP) on barrier function skin and permeation a model macromolecule in combination with different formulations. Skin samples were treated EP treatment for 2 min. Firstly, examined mouse vivo by measuring transepidermal water loss (TEWL). Then, human investigated ex under fluorescence microscope solution, h...

the water content of the epidermis is a main factor in maintaining skin smoothness and elasticity and preventing skin dryness. occlusive products can greatly affect skin hydration by forming a barrier on the skin following the topical administration of oil-based formulations. these products repair the skin barrier by restoring the skin lipids as well. solid lipid nanoparticles (slns) have recen...