background and objectives: angiogenesis is essential for growth and metastasis of solid malignancies. tumor vessel count and expression of vascular endothelial growth factor (vegf), a potent angiogenic factor, have been associated with prognosis. this study was designed to assess vessels density by using cd31 and cd105 (endoglin) and their correlation with expression of vegf and proliferative i...

hepatitis b virus (hbv) infection is the 10th leading cause of death worldwide. the most important diagnostic and screening marker for hbv infection is hepatitis b surface antigen (hbsag), and the most widely used hbsag screening test is enzyme-linked immunosorbent assay (elisa). in this study, an elisa assay has been developed for detection of hbsag using two novel monoclonal antibodies (mab) ...

background: application of adjuvants with microbial origins is a recently highlighted approach in the vaccinology trials. archaeosomes are among these microbial compounds with both adjuvant and liposomal activities and features. methods: in the present study, recombinant hbsag encapsulated into methanobrevibacter smithii (m. smithii) archaeosomes. balb/c mice immunized with this compound and hu...

background to evaluate the strength of association and to determine the best prediction of response in terms of sensitivity and specificity among quantitative baseline hbv-dna levels in blood serum in patients with chronic hepatitis b (chb) infection who treated with interferon-alpha-2b. patients and methods totally, 78 chb patients with serum hbv-dna>105 copies/ml were treated with interferona...

conclusions these results exhibited the immuno potentiator effects of mip-3beta plasmid when coadministrated with the hcv core dna vaccine. complimentary studies integrating mip-3beta as a genetic adjuvant in hcv-core-dna vaccination models are warranted. results mice covaccinated with mip-3beta elicited an enhanced th1 biased systemic immune response as evidenced by higher ifn-γ/il-4 and anti-...

Tumor vaccines, focusing on tailoring individual tumor antigens, have gained much attention in personalized therapy.

background: tumor associated antigens can be viably used to enhance host immune response.objectives: the immunomodulatory effect of biogenic selenium nanoparticles (senps) was compared between treated and untreated mice with crude antigens of 4t1 cells.materials and methods: female inbred balb/c mice (60) were injected by cancinogenic 4t1 cells causing breast cancer. after 10 days, all tumor be...

  Partially fed (4 -5 days) H .a. anatolicum (Iranian isolate) female adult ticks were used for preparation of antigens of midgut which are, the gut supernate antigen (GS), gut membrane antigen (GM), triton extracted gut membrane antigen ( TX-GM ) and sodium dodecyl sulphate treated Triton extracted gut membrane antigen (SDS-TX-GM). The New Zealand white rabbits were immunized with GS, GM, TX- ...