The article by Abboud et al. investigating the outcome of neuromyelitis optica (NMO) relapses treated by steroids alone or in association with plasma exchange (PLEX) demonstrates a better outcome in PLEX-treated attacks with a higher proportion of patients improving to baseline Expanded Disability Status Scale (EDSS): 65% vs 35%. Considering the high level of significance of their results, they...

Neurology 2008;71:620–621 Since the emergence of the modern therapeutic era in multiple sclerosis (MS), the field has focused on identifying agents to prevent long-term disability progression. In lieu of measuring the true endpoint of interest, long-term disability progression, clinical trials typically measure surrogate endpoints, such as short-term disability progression or changes in lesion ...

One possible explanation for this result is the size of the standard deviations of the measurements, which might be related to the wide range of Expanded Disability Status Scale (EDSS) scores permitted for patient inclusion. We are aware that a smaller range of EDSS scores would have selected a more homogeneous sample of subjects and probably would have reduced the size of the standard deviatio...

The Expanded Disability Status Scale (EDSS) has been the most widely used measure of disability in multiple sclerosis clinical trials. Although EDSS has the advantage of familiarity with respect to recent proposals, yet is difficult to use consistently between evaluators. AEDSS (Automatic EDSS) is a computerized system designed to overcome this problem. It constrains the neurologist to follow p...

BACKGROUND Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwMS). METHODS We interviewed 42 pwMS receiving natalizumab and collected clin...

OBJECTIVE To assess the comparative utility of disability progression measures in primary progressive MS (PPMS) using the PROMiSe trial data set. METHODS Data for patients randomized to placebo (n = 316) in the PROMiSe trial were included in this analysis. Disability was assessed using change in single (Expanded Disability Status Scale [EDSS], timed 25-foot walk [T25FW], and 9-hole peg test [...

background: in adults, throughout life, uniqueness maintains the equivalent; but, it might be tailored in the track of neurological disarrays. as in the partition of cognitive function associated with multiple sclerosis (ms), numerous studies have been performed, but there are very few reports in this area of behavior. the aim of this study was to investigate the prevalence of personality types...

OBJECTIVE To investigate the value of Expanded Disability Status Scale (EDSS) worsening sustained for at least 6 months and other parameters as predictors for disability status. DESIGN Retrospective analysis of the Multiple Sclerosis Collaborative Research Group study data. SETTING The intramuscular interferon beta-1a pivotal trial was a double-blind, placebo-controlled phase 3 study. PAR...

Background: Multiple sclerosis (MS) is known to affect essentially the central nervous system; however, peripheral nerve involvement, as an additional cause of disability, has been recently noticed. Objectives: This study was aimed to perform detailed electrodiagnostic assessments in MS patients to evaluate peripheral nervous system involvement. Materials and Methods: A total of eighty MS...