Periodontitis is one of the severe complications in diabetic patients and gingival epithelium plays an initial role on the onset and progression of this disease. However the potential mechanism is yet sufficiently understood. Meanwhile, the research on the correlational experimental animal models was also insufficient. Here, we established periodontitis with type 2 diabetes in db/db and Tallyho...

An acidic microenvironment formed by vacuolar ATPase (V-ATPase) expressed in plasma membranes of osteoclasts is thought to be indispensable for bone resorption. This study examined the efficacy of a novel V-ATPase inhibitor, FR202126, in reducing alveolar bone loss caused by experimental periodontitis in rats. FR202126 inhibited H+ transport in plasma membrane vesicles of murine osteoclasts, wh...

The purpose of this study was to determine how accurately periodontal probes measure connective tissue attachment levels in beagle dogs with (1) clinically healthy gingivae, (2) experimental gingivitis, and (3) periodontitis. In the healthy and experimental gingivitis specimens the probes were inserted with a standardized force of 25 ponds. In periodontitis specimens the probes were inserted wi...

PURPOSE We previously reported that human serum significantly reduces the invasion of various oral bacterial species into gingival epithelial cells in vitro. The aims of the present study were to characterize the serum component(s) responsible for the inhibition of bacterial invasion of epithelial cells and to examine their effect on periodontitis induced in mice. METHODS Immortalized human g...

BACKGROUND The anti-inflammatory effects of a homeopathic remedy, Traumeel S, have been observed in experimental and clinical studies; however, its antioxidant properties have not been elucidated. The aim of the present study was to evaluate the antioxidant effects of Traumeel S on peripheral blood neutrophils in patients with periodontitis. MATERIAL/METHODS The study was performed using veno...

The influence of supragingival plaque control on the subgingival microflora and clinical parameters of ligature-induced periodontitis in the Cynomolgus monkey was investigated. No clinical changes were observed during the six-week experimental period. The total cultivable flora and the proportions of total black-pigmented Bacteroides (BPB) and asaccharolytic black-pigmented Bacteroides decrease...

objective: administration of amoxicillin and metronidazole along with scaling and root planning (srp) is an effective adjunctive therapy for chronic periodontitis. studies have shown that administration of azithromycin is also effective for treatment of chronic periodontitis. this study aimed to compare the effect of short-term and long-term azithromycin regimen with amoxicillin and metronidazo...

Increasing epidemiologic evidence supports a link between periodontitis and rheumatoid arthritis. The actual involvement of periodontitis in the pathogenesis of rheumatoid arthritis and the underlying mechanisms remain, however, poorly understood. We investigated the influence of concomitant periodontitis on clinical and histopathologic characteristics of T cell-mediated experimental arthritis ...

The purpose of this study is to evaluate the effect of the avocado/soybean unsaponifiables (ASU) on the treatment of induced periodontitis in rats. Periodontitis was induced in 84 rats via ligature placement around the second upper molar, which was removed after 7 days, and scaling and root planning (SRP) was performed at this time. Subsequently, the rats were randomly allocated to four groups ...

Objectives The frst cause of tooth loss in developed countries is periodontitis and mostly occurs in people over 40 years old.Atorvastatin is a statin drug class, which has a revolutionary impact on the treatment of high cholesterol and also stimulates bone morphogenic protein which has osteogenic potential. The aim of this study was to evaluate the effect of local and systemic Atorvastatin in...