Shear stress in suspension culture was investigated as a possible manipulative parameter for the control of glycosylation of the recombinant tissue-type plasminogen activator protein (r-tPA) produced by recombinant Chinese hamster ovary (CHO) cell culture, grown in protein-free media. Resulting fractions of partially glycosylated, Type II, and fully glycosylated, Type I, r-tPA protein were moni...

A liquid film is studied that is deposited onto a flat plate that is inclined at a constant angle to the horizontal and is extracted from a liquid bath at a constant speed. We analyse steady-state solutions of a long-wave evolution equation for the film thickness. Using centre manifold theory, we first obtain an asymptotic expansion of solutions in the bath region. The presence of an additional...

Networks of aggregated colloidal particles are solidlike and can sustain an applied shear stress while exhibiting little or no creep; however, ultimately they will catastrophically fail. We show that the time delay for this yielding decreases in two distinct exponential regimes with applied stress. This behavior is universal and found for a variety of colloidal gel systems. We present a bond-ru...

We discuss the structure of the local error of exponential operator splitting methods. In particular, it is shown that the leading error term is a Lie element, i.e., a linear combination of higher-degree commutators of the given operators. This structural assertion can be used to formulate a simple algorithm for the automatic generation of a minimal set of polynomial equations representing the ...

In this article fluid-structure interaction of vibrating composite piezoelectric plates is investigated. Since the plate is assumed to be moderately thick, rotary inertia effects and transverse shear deformation effects are deliberated by applying exponential shear deformation theory. Fluid velocity potential is acquired using the Laplace equation, and fluid boundary conditions and wet dynamic ...

The dynamic performance of structures under traveling loads should be exactly analyzed to have a safe and reasonable structural design. Different higher-order shear deformation theories are proposed in this paper to analyze the dynamic stability of thick elastic plates carrying a moving mass. The displacement fields of different theories are chosen based upon variations along the thickness as c...

The goal of this work is to study the large sample properties of the posterior-based inference in the curved exponential family under increasing dimension. The curved structure arises from the imposition of various restrictions, such as moment restrictions, on the model, and plays a fundamental role in various branches of data analysis. We establish conditions under which the posterior distribu...

The velocity and stress autocorrelation decay in a dissipative particle dynamics ideal fluid model is analyzed in this paper. The autocorrelation functions are calculated at three different friction parameters and three different time steps using the well-known Groot/Warren algorithm and newer algorithms including self-consistent leap-frog, self-consistent velocity Verlet and Shardlow first and...

We consider the dynamics of a polymer with finite extensibility placed in a chaotic flow with large mean shear, to explain how the polymer statistics changes with Weissenberg number, Wi , the product of the polymer relaxation time and the Lyapunov exponent of the flow, λ̄. The probability distribution function (PDF) of the polymer orientation is peaked around a shear-preferred direction, having ...