Extracellular vesicles participate in intercellular communications, altogether with classic mechanisms like direct contact between cells and the secretion of mediators. They have attracted considerable interest since their discovery reticulocytes 1983. The term includes different types that vary size origin, exosomes, microvesicles apoptotic bodies as major ones. These structures are sorrounded...

The ability of an organism to sense cellular, extracellular, or environmentally derived signals, to integrate that information, and to respond appropriately is broadly termed signal transduction and is fundamental to the survival of that organism. In our first biochemistry course, most of us were exposed to specific metabolites, but likely only in terms of being intermediates or cofactors of a ...

Dopamine (DA) is responsive to hormonal manipulations and has been implicated in the regulation of female rat sexual behavior. In the present studies, extracellular DA levels were assessed in the medial preoptic area (MPOA) of ovariectomized female rats in response to exogenous ovarian hormones and during sexual activity. In female rats primed with a low dose of estradiol benzoate (2 microg), b...

The ability of an organism to sense cellular, extracellular, or environmentally derived signals, to integrate that information, and to respond appropriately is broadly termed signal transduction and is fundamental to the survival of that organism. In our first biochemistry course, most of us were exposed to specific metabolites, but likely only in terms of being intermediates or cofactors of a ...

The ability of an organism to sense cellular, extracellular, or environmentally derived signals, to integrate that information, and to respond appropriately is broadly termed signal transduction and is fundamental to the survival of that organism. In our first biochemistry course, most of us were exposed to specific metabolites, but likely only in terms of being intermediates or cofactors of a ...

The intracellular synthesis and retention of polygammaglutamyl derivatives of methotrexate, 4-amino-10methylpteroylglutamate (4-NH2-10-CH3-PteGlul), and their interactions with dihydrofolate reductase were evaluated in the Ehrlich ascites tumor cell in vitro by high pressure liquid chromatography. The accumulation of these metabolites was increased over 5-fold by the addition of 5 m~ L-glutamat...

The ability of an organism to sense cellular, extracellular, or environmentally derived signals, to integrate that information, and to respond appropriately is broadly termed signal transduction and is fundamental to the survival of that organism. In our first biochemistry course, most of us were exposed to specific metabolites, but likely only in terms of being intermediates or cofactors of a ...

The ability of an organism to sense cellular, extracellular, or environmentally derived signals, to integrate that information, and to respond appropriately is broadly termed signal transduction and is fundamental to the survival of that organism. In our first biochemistry course, most of us were exposed to specific metabolites, but likely only in terms of being intermediates or cofactors of a ...

The ability of an organism to sense cellular, extracellular, or environmentally derived signals, to integrate that information, and to respond appropriately is broadly termed signal transduction and is fundamental to the survival of that organism. In our first biochemistry course, most of us were exposed to specific metabolites, but likely only in terms of being intermediates or cofactors of a ...

The apparent diffusion coefficients (ADCs) of a series of markers concentrated in the extracellular space of normal rat brain were measured to evaluate, by inference, the ADC of water in the extracellular space. The markers (mannitol, phenylphosphonate, and polyethylene glycols) are defined as "compartment selective" because tissue culture experiments demonstrate some leakage into the intracell...