Background: Extrahepatic biliary atresia (EHBA) is a chronic progressive obstructive cholangiopathy of infancy of unknown aetiology. Pathology of bile duct damage involves unanimously neutrophil elastase, variable degrees of fibrosis, and variable CD14+ monocytes intensity staining in the presence of defective p53 and glutathione S transferases Pi class (GST Pi). GST is a super family responsib...

background liver cirrhosis is one of the major causes of hospitalization and mortality in children. a wide spectrum of disorders including developmental abnormali­ties, infections, metabolic and genetic disorders can lead to liver cirrhosis in pediatric patients. determination of its etiology is important for treatment mo­dality, prevention of progressive liver damage, family counseling and pri...

Calreticulin plays a critical role in the etiology of multiple autoimmune diseases. It is unknown, however, whether calreticulin levels are of clinical significance for patients with biliary atresia. This study was to confirm possible correlations between serum calreticulin levels and the immunohistochemical features of biliary atresia. Serum was collected from 44 biliary atresia patients, 15 i...

Biliary obstruction is a common clinical manifestation of various conditions, including extrahepatic cholangiocarcinoma. However, a screening test for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction is not yet available. According to the rationale that the biliary system plays a major role in lipid metabolism, biliary obstruction may interfere with lipid profil...

Biliary atresia, malrotation, meconium peritonitis and transient hypothyroidism are occasionally seen in neonatal infants. Biliary atresia associated with malrotation has been reported in some patients with polysplenia syndrome, but biliary atresia associated with meconium peritonitis has only been described by a few investigators. Here we present a case of meconium peritonitis due to malrotati...

Scintiscans of liver and spleen using technetium 99m sulphur colloid in 15 infants with extrahepatic biliary atresia and 11 infants with severe obstructive jaundice (7 with genetic deficiency of alpha 1-antitrypsin) showed similar hepatic size, pattern of isotope uptake, and splenic abnormality with no distinguishing features. In 37 older children with a variety of liver disorders, the scan was...

Neonatal cholestasis is a prolonged elevation of the serum levels of conjugated bilirubin beyond the first 14 days of life. Commonest etiologies include extrahepatic conditions like biliary atresia, intrahepatic like congenital malformations, infections and inborn errors of metabolism. TORCH infections constitute 22% cases of neonatal hepatitis, of which Cytomegalovirus is the commonest agent. ...