Metoclopramide is a dopamine antagonist in the central nervous system and an antiemetic agent. It can cause extrapyramidal symptoms side effects such as dystonic reactions characterized by involuntary, sustained or spasmodic contractions of muscle groups, resulting twisting, repetitive abnormal postures. In this study, we aimed to report pediatric patient who presented with acute dystonia due m...

Pharmacological treatment remains the mainstay of the management of schizophrenia. Older, "typical" antipsychotics carry a significant burden of side effects, notably extrapyramidal and neurocognitive side effects. Newer, "atypical" agents carry a lower risk of extrapyramidal side effects. They appear to have added benefit for treating negative and cognitive symptoms of schizophrenia, and hence...

We report an elderly patient who developed severe delirium and extrapyramidal signs after initiation of lithium-olanzapine combination. On hospital admission, serum levels of lithium were found to be 3.0 mM/L which were far above toxic level. Immediate discontinuation of both drugs resulted in complete resolution of most of the symptoms except for perioral dyskinesia which persisted for three m...

OBJECTIVE To describe a case of vitamin B(12) deficiency with classic and rare clinical features and novel radiographic features. DESIGN Case report. SETTING Johns Hopkins Hospital neurology service. PATIENT Middle-aged man with neuropathy, myelopathy,impaired cognition, and extrapyramidal signs. RESULTS The patient had neurologic and hematologic signs of vitamin B(12) deficiency, with ...

Interleukin-6 (IL-6) is one of the most important pro-inflammatory markers with immunomodulatory activity associated schizophrenia. The possible involvement interleukin-6 in etiopathogenesis schizophrenia and development different clusters symptoms remains debatable; relationship between an increase a number confounding factors, including smoking, has not yet been studied. aim this work was pil...