Ocular enucleation produces significant morphological and physiological changes in central visual areas. However, our knowledge of the molecular events resulting from eye enucleation in visual brain areas remains elusive. We characterized here the transcription nuclear factor kappa-B (NF-κB) activation induced by ocular enucleation in the rat superior colliculus (SC). We also tested the effecti...

We observed a young woman who showed growth of a choroidal melanoma over the course of 2 pregnancies, with subsequent enucleation of the eye. This is the first such documented case. In addition 4 other women with uveal malignant melanomas presented during pregnancy. This observed number of pregnancies (5) was greater than the expected number (2.1) among women of childbearing age who underwent e...

Until the late eighties, the only treatment available for uveal melanoma was enucleation of the affected eye, though brachytherapy, thermotherapy and radiation therapy can be used to treat small/medium size tumours with preservation of the eye [16]. Several different chemotherapeutic agents have been used, such as Dacarbazine, alone or in combination with Interferonalpha 2b, after primary treat...

Methods: A 55-year-old woman with a ring melanoma was scheduled for enucleation. The eye (visual acuity 20/ 20) had a healthy-appearing macular retina. The retina was exposed to light from a commercially available class 3A green laser: 60 seconds to the fovea, 5 minutes to a site 5° below the fovea, and 15 minutes to a site 5° superior to the fovea. Color photographs were obtained before and af...

A 52-year-old man was diagnosed as having a large malignant melanoma of the choroid in the right eye. Six years later his 58-year-old wife of almost 40 years was diagnosed as having a large malignant melanoma of the choroid in her left eye. In both patients the diagnosis was confirmed histologically following enucleation. Electron microscopy failed to reveal evidence of viral particles within t...

BACKGROUND/AIMS To report a case and the unique histopathology of a necrotic uveal melanoma mimicking advanced Coats' disease in a young adult. METHOD A 26-year-old male presented with a blind, painful eye, total exudative retinal detachment, and bulbous aneurysms consistent with Coats' disease. No masses were visualized on ultrasound or CT scan, and the patient underwent enucleation of the e...

OBJECTIVE To determine optimal scissor blade design and surgical approach to facilitate obtaining a long optic nerve segment during enucleation procedures. METHODS Two hundred mock enucleations were performed with the use of a human child skull model and a silicone sphere to simulate an eye. Temporal and nasal approaches with scissor blades with noncurved, mildly curved, or strongly curved bl...

A clinicopathologic correlation between two patients with acute-onset Aspergillus endophthalmitis undergoing enucleation is reported. These two patients presented with pain, redness, and decreased vision following uncomplicated cataract surgery. In both patients, vitreous aspiration and intravitreal injections were the initial treatment followed later by pars plana vitrectomy for clinical worse...

A retrospective study was made of the effectiveness of an eye bank decontamination and storage method. A comparison was made between microbial cultures taken from the limbus at enucleation and from scleral remnants recovered after surgery. Organisms were isolated from the limbus of 73% of donor eyes and from 4% of remnants. Standard eye bank procedures were found to eradicate gut and skin organ...